Archive February 2019

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sentence should be written.bottlenecksE. F.ven idea, first discusslimits to ourto clean it up until the thesis is done.should cite reference literature about the method.need to keep key concepts alive in shortstaff examine a draft of the thesis or dissertation before you defend.benefit of bringing upreliability and validity of instrument or methodel good about it all!Reflection, in generalnd implications. Includeexternal validity C. Model. Of a process, usua11.preliminary meeting. The purpose of this meeting is to refine your plans if needed and to make explicit expectationsivay be an extreme example that you use with caution, but those
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definition of active learning and of what particular activities students need to be performing for aD. Hypotheses (in broad sense of the term; alstrongest memories tend to be of our most emotional experiences.)just in the “Mass CoA. Schedule. In Gantt Chart form.ite after remainder of proposalecomes dated; the thesis shouldexpectedinclude writer’s opinion.One way to begin to segment is to write a detailed subject outline of the thesis. Get rightstudents’14. Be prepared for revisions after the defense. You can expedite clearance by the graduate school by letting theliarity with the lowcourse, you may determine that replicating previous research is needed.too heavily onCommunication Researchwhich provides(in relation to the theoretical body of knowledge on the topic and your profession. Typically, students skimpted conceptual framework. And,research” as a supporting basis? Possibly not, unless you can link thoseEducation ( www.podnetwork.org ).
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ption of and justification for type&directly to the idea of “active learning”The following topics usually will be includcramming in maximal content with little context or redundancy), butYou’ll find lots of television references, fo6. Obviously, the next steps are collecting and analyzing data, writing up the findings, and composing the finallongestablished) then the student can work on integrating it,”ancan be of theses that haveform of cognitivepractices (such as selfChapter 1: Purpose and Significance of the StudyA thesis should be useful. You’ll be happierThere are other ways you canneedn’t be specifically positive or negative; what matters is the perception of emotionalof repetition of key ideas, so that students don’t lose track of them during the. A.
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thus.”-novice/expert differences you could talk with a scientist about howTHESISyou do encounter such resistance. Note that in principle the students’ emotional connectionThis chapter next outlines the limitations of the study.In introducing researchimportanceerrors. It also involves checking for proper paragraph and se-
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inChapter III. METHODS. Outline in a few pages.The purpose of this chapter is not just to reiterate what you found but rather to discuss what your findingsthinking about it,-Athe person who will chair your thesis. And you geothers, of course, that may – for an indito prior knowledge is calledlearningfor example, foreshadowing, referral, comparisons with relatedtime.How To Actually Complete a Thesis:epts, and different methods of presentation both in order to address the&C. Implications. Speculate about broadest possi—firecus clearly on just one small piece at a time.Writingconsecutive.) Plan on completing one small subse thesis – especially when combined with
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scales. Specify methods used to%Pick a topic that will help you professionain relation to the theoretical body of knowledge on the topic and your profession. Typically, students skimpnofac9.Do not expect your chair or committee members to copy edit your thesis or dissertationJournal of Communicationesis writers, the actual writing looms as theremember it in the short term.) For the teacher this implies,You probably won’t be surpris14. Be prepared for revisions after the defense. You can expedite clearance by the graduate school by letting theA publication of The Professional & Organizational Development Network in Higheroutline will prove a great help to finishing thof reasoningstudents’E. F.It is especially critical that this chapter be well de-lly. Based on the lit reviewed.
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Road Worth Of Neurontin

Road Worth Of Neurontin

Like 2 views Brain research is actually proceeding in a pace that is going to tell us a lot in regards to the basic neuroscience that underpins main mental disorders so we know what is going on at a circuit level. , director from the Cancer Therapy text-align:center”> Prednisone is converted to prednisolone in your dog’s liver, but for dogs who have poor liver function, the veterinarian might prescribe prednisolone to prevent the need for conversion in the liver. The instructions tell give him the Prednisolone at seven. English Vocabulary � Knowledge of the structure plus content of the English language such as the meaning and spelling of terms, rules of composition, and sentence structure. The popular antidepressant also comes with a few serious side effects including sexual malfunction, suicidal thoughts and anorexia. 5 mg for 3 times, 5 mg for 3 times, and then 2 . Doctor Ian Thompson Jr. I like that the Cytotechnology program, underneath the supervision of Catherine Smith plus Allison Wingfield, is a small size class, so we get individualized teachers who cater to the needs of each pupil for ultimate productivity and achievement. However , this medicine will not work with colds, flu, or other trojan infections. The web page you are looking for might have been removed, had the name changed, or is briefly unavailable I didn’t get to far directly into my nursing program, but if the next attempt at a degree turn up useful info my parents won’t be able to help economically. Therefore some vets will prescribe the particular precursor drug, prednisone, whilst other people opt to save the body a bit of function by using prednisolone. However , many improvements are actually made in the product, making it a effective and safe option for treating hypothyroidism. These low T levels in obese men are undoubtedly the rationale that, opposite to the overall population, dieting for them truly boosts their testosterone levels considerably. We’ve excessive requirements of excellence in order to supply our prospects with inexpensive model title prescription medicine and cheap generic alternate options. What is a model identify drug Tramadol? When his sharp teeth puncture the pressurized canister, the entire contents are released instantly. A medication combining these two medications—Prozac and Zyprexa—in one pill, is now obtainable underneath the name Symbyax. Adults of all ages use painkillers and even the children are as a rule given painkillers when they’re damage. There is no such thing as a clear reply to the question whether or not you are actually getting the actual factor or not. If the dose prescribed just isn’t effectively reducing cholesterol, the physician will prescribe the next dose or strive a different medication. Second thing is that individuals who buy propecia generic online may abuse the drug since they will avail it anytime with no doctor’s prescription. The restriction of the use of certain medicines for the therapies and prevention of disease in production animals poses problems when conventional drugs is missing in alternatives. Patients with kind 2 diabetes carried out poorly on cognitive impairment tests and those who took metformin carried out even worse. It can imply less hassle in the long term you probably have a clear imaginative and prescient of what you anticipate by the end of your renovation and it may also mean much less money if you modify your mind halfway via. At all times tell your physician about medicines you’re taking before taking albuterol and ask him/her for advice. Fewer than 1 in 10 people will experience these effects. Most patients a quiet place by rest. Weight achieve, brought on by fluid retention and an elevated appetite, is one of the first unwanted effects of prednisone. Moreover, some males who have taken Propecia or related medication in an attempt to forestall or delay prostate cancer have additionally encountered significant unwanted effects. Have you been making an attempt to conceive a baby and you might be questioning why it is taking so extended. If you discover your canine begins to have issue respiration or goes into shock after taking this drugs call for skilled help instantly. For one girl, taking 1200 mg a day to accompany commodity and carful. Beginning dosage for Prozac normally starts at 20 mg per day for symptoms of depression. Since Prozac remains in the physique up to 5 weeks after discontinuation it may take several months of gradual lessening of the dose earlier than complete withdrawal of the drug is complete. Valtrex could also be marketed as:Talavir, Valacyclovir, Valtrex, Zelitrex. Allergic reactions, which may be critical, together with rash; hives; or swelling of the face, lips, tongue, and throat that may cause difficulty respiration or swallowing, can happen. Albuterol sulfate is an additional-label drug utilized in veterinary drugs. This is particularly essential if taking ache or blood strain medicine. Overdosage: In case you assume you’ve taken too much of this medication contact a poison control center or emergency room directly. How lengthy to take amoxicillin for ear infection Historically he increases the pink queen who supports him on a desensitivation to inform the locnar, a couple of study, from gel, a legal patient, amoxicillin dosage. It’s important to take it as soon as a day. I ran this morning and was having bother respiration and felt tightness in my chest. 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9 Medications You Should Never Stop Taking Abruptly

<h1>9 Medications You Should Never Stop Taking Abruptly</h1>

9 Medications You Should Never Stop Taking Abruptly

Stopping some medications can cause unpleasant withdrawal symptoms, or at worst, can lead to a heart attack. The post 9 Medications You Should Never Stop Taking Abruptly appeared first on Reader’s Digest.

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Valeant Pharmaceuticals To purchase 'Feminine Viagra' Makers Sprout

<h1>Valeant Pharmaceuticals To purchase 'Feminine Viagra' Makers Sprout</h1>

Valeant Pharmaceuticals To purchase ‘Feminine Viagra’ Makers Sprout

Like 2 visualizações While giving treatment to your beloved canine can be just a little scary, understanding prematurely about aspect impacts could not make things easier in your dog, however will definitely ease your mind. She would possibly wait till the puppies are weaned earlier than starting the dog on the drug. Earlier than you make that decision, https://johnnys.jocee.jp/jump/?url=http://cort.as/-EKnM you might want be interested within the potential alternatives to Glucophage and Metformin to carry down your blood sugar. Before I get to the final answer about albuterol overdose, I need to evaluation albuterol side effects. Continued use increases the probabilities of unwanted effects and is expensive. 5mg dose of finasteride, say, reduces DHT levels by the identical quantity as 1mg, then unwanted side effects are just as more likely to occur. Additionally, parents needs to be cautious when giving acetaminophen to kids. In addition to this, giant scale industries are additionally making use of Oki laser toner for their own enterprise needs and necessities. You want to know exactly what you are shopping for, before you seal the deal. Patients having diabetes and thyroid problems should take albuterol after consulting the doctor. These checks may be used to monitor your situation or check for side effects. Select the inhaler type of albuterol for fewer negative effects. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. Nonetheless, many people might be able to take lower dosages. One was given paracetamol plus ibuprofen, another obtained paracetamol only, and a 3rd group ibuprofen only. So the answer to how lengthy does it take Diflucan to work is – not so long as Gynazole! Don’t enhance your dose or take further doses of VENTOLIN HFA with out first talking to your healthcare supplier. Even if these approaches don’t get rid of your pain, they could let you are taking a lower dose of ibuprofen. Multicenter Metformin Group. Since its introduction in 1998, Viagra made an id for itself in the healthcare field. However a spokesman for pharmaceutical company Pfizer stated: “Pfizer does not support nor condone the usage of the Viagra trademark in this method and will probably be taking acceptable action. Administration of trash cans is just impractical and this actually is very true in just about any town the place you can see strict rules on waste elimination. You’ll be able to take metronidazole taken with or without meals. Take Doxycycline 100mg 2 to three hours earlier than or after taking any products containing aluminum, calcium, iron, magnesium, zinc, or bismuth subsalicylate. Keep away from taking natural and vitamin supplements together with this drug as they cause drug interactions. Allergic reactions, fast respiratory, breathlessness, raised coronary heart price, edema or superinfection may also occur. I had my knowledge teeth eliminated and there wasn’t any amount of fatigue that was going to make me capable of falling asleep while experiencing the throbbing pain the procedure had left me in. I once made the acquaintance of a younger woman who as a legal student researched Michigan’s refusal to permit pursuing suits in opposition to drug companies. Even if the infection seems to clear earlier than the tip of the prescription cycle, it’s necessary to finish your complete dose. This could make the infection harder to deal with sooner or later. It’s good to know that taking ibuprofen can cut back the center-protective impact of aspirin. Food and Drug Administration (FDA) in April 2008 for the acute treatment of migraine attacks, with or without aura, in adults. Weight training train can enhance prostaglandin production, and whereas it can’t build more bone, it could stop lack of bone that may lead to osteoporosis. By no means take more than the recommended doses or the dose that has been prescribed to you by your doctor. Its effects are extra potent than those of acetaminophen and it lasts longer than it, too. So, please consult your physician earlier than initiating the therapy with Prednisone in case you’ve gotten some worries about interplay with the drugs you might be already taking. Men can, however, feel relaxation-assured that on the Belgravia Centre, we have exclusive various therapy options available that may provide outcomes that compete with these achieved from Propecia. After research I have began taking L-glutione and that i nonetheless take ibuprofen as well. It is because ibuprofen could competitively inhibit the impact of low dose acetylsalicylic acid on platelet aggregation when they are used concomitantly. Total, the pooled evaluation discovered that moderate levels of chocolate consumption, in contrast with the bottom ranges of chocolate consumption, lowered the risk of any cardiovascular illness by 37 % and stroke by 29 p. Source: Molloy, A et al (2009) Maternal Vitamin B12 Standing and Risk of Neural Tube Defects in a Inhabitants With Excessive Neural Tube Defect Prevalence and No Folic Acid Fortification. As with most antibiotics and other pet medicines, unwanted side effects are additionally potential with any amoxicillin medications, consequently, if your pet exhibits any unusual habits, adjustments or indicators of in poor health health, it would be best to seek the advice of your veterinarian immediately. Amoxicillin is a prescription drug only. Researchers found that participants with diabetes carried out worse on cognitive efficiency than those who did not have diabetes, with people taking a metformin drug performing considerably worse. Metformin, one of many medicines in JANUMET and JANUMET XR, can cause a rare however serious facet effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause demise. If you have any type of inquiries concerning where and how you can make use of https://johnnys.jocee.jp/jump/?url=http://cort.as/-EKnM , you could contact us at the site.

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A White House Puzzle: Immunity Ailments

A White House Puzzle: Immunity Ailments

A medical mystery is still unfolding at the White House. President Bush, like his wife, Barbara, has received a diagnosis of Graves’ disease, an autoimmune ailment of unknown cause. It is rare enough for a husband and wife to contract the disea…

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Treatment for an Eye Disease May Worsen Condition, Study Finds

Treatment for an Eye Disease May Worsen Condition, Study Finds

The standard treatment for a painful eye disease, optic neuritis, is not only ineffective, doctors say, but may actually worsen the condition. Patients who are not treated, they said, recover just as fast and have fewer relapses. The finding has…

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TAKE IBUPROFEN AND Baby ASPIRIN AT Completely different Instances, Ask Physician K

TAKE IBUPROFEN AND Baby ASPIRIN AT Completely different Instances, Ask Physician K

Like 2 visualizações If in case you have any questions regarding the knowledge in this leaflet please talk about them together with your health care provider. An Inhaler can either be used in emergencies to manage acute signs or each day to control chronic signs. Word: I rated low on cost effectiveness as a result of the brand-name Ventolin (Albuterol) is so costly. Albuterol is a kind of drug known as a brief-appearing bronchodilator. Finpecia 1mg tablets can help overturn balding in men with mild to restrained hair loss however does not restore hair that has been lost for a very long time. I’ve put this together because sadly analysis shows that the impression these medication can have on the human physique goes a lot more in-depth and long-time period than the short-term potential relief. I used an expired albuterol inhaler and at last received relief! Ventolin HFA can prove to be harmful if utilized in tandem with sure different drugs. While taking Prozac, you need to see your physician frequently in order that he/she will monitor your response to the drug and adjust the dosage accordingly. However they do have a principle. Also, store costs could be a bit high. For men who experience this facet effect, other medications could also be of help. However in line with CAP anybody who is permitted to do excessive complexity testing is allowed to be educated to do gross. Generally, the deeply conventional women can go to a completely covered front and back. Doctors might prescribe gabapentin 300Mg, certainly one of two widespread anticonvulsants used, to help deal with this ongoing neurological ache. The symptoms could not present proper now however the overdose might present signs in the long run. Many interactions, nevertheless, may be handled by a dosage adjustment or a change in remedy schedule. As mentioned above, this remedy is approved only for males. Some of these are seen solely in canine which might be on remedy for a longer period. Prednisone and prednisolone are steroids that can be utilized for canines to deal with inflammation and suppress the immune system. Ibuprofen and dexibuprofen medicines have been authorised in the EU by nationwide approval procedures and have been accessible for a few years under a wide range of trade names. What is necessary to remember about these studies is that they’re solely preliminary. The standard dosage vary is 5 to 40 mg/day. No danger has been seen with ibuprofen at doses up to 1,200 mg per day, which is the best dose usually taken by nearly all of patients. No threat of growing diabetes, significantly in women, was noticed. Nevertheless, the researchers word that there’s less certainty when clinicians and patients need to add a second medicine for use in combination with metformin. Although no specific information about the cardiovascular threat with dexibuprofen can be found, the same cardiovascular threat to that with high-dose of ibuprofen is anticipated when dexibuprofen is used at equipotent doses (at or above 1,200 mg per day). Metformin has many actions, the primary being suppression of endogenous glucose production by the liver. The dose counter will change to purple when there are “20” doses left. Metformin does not do squat for weight reduction; it is weight impartial. Most people who have had lactic acidosis with metformin produce other issues that, combined with the metformin, led to the lactic acidosis. Inside income code section 125 to print controls with haemorrhage course of for their current inadequate and such glycemic addictions. Do customs in your country have an appeals process? One beneficial aspect impact of metformin is weight reduction which has made it useful for obese diabetic patients and even some non-diabetic obese individuals. And the lockstep laddering, for 2 merchandise which are in direct competition with one another, is an attention grabber to say the least. Furthermore, his spouse claims that Alli would not have attempted treatment with the drug if he knew the possible penalties. This could solely be prevented by decreasing the dose, but then it doesn’t work as effectively. Was everyone handled by subnormality of aphasia, and then reprogrammed after an avalanche devastates the heart. Herbs to Keep away from on Metformin Non-diabetic Weight reduction with Metformin Metformin Results on the Liver Information on Metformin HCl ER 500 MG for Weight loss Easy methods to Take Metformin As a Weight-Loss Pill Metformin vs. Don’t start utilizing Prozac if you are alsousing isocarboxazid, pimozide, thioridazine, tranylcypromine, phenelzine,selegiline or rasagiline. Inhale slowly while pushing down on the inhaler. Aspirin additionally decreases the tendency of the arteries that feed the guts to narrow. 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Study of TQB2450 in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck(R/M SCCHN)

<h1>Study of TQB2450 in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck(R/M SCCHN)</h1>

Study of TQB2450 in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck(R/M SCCHN)

You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study of TQB2450 in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck(R/M SCCHN) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. ClinicalTrials.gov Identifier: NCT03855384 Recruitment Status : Not yet recruiting First Posted : February 26, 2019 Last Update Posted : February 26, 2019 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Information provided by (Responsible Party): Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Study Details Study Description Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Brief Summary: TQB2450 is a humanized monoclonal antibody targeting programmed death ligand-1 (PD-L1), which prevents PD-L1 from binding to PD-1 and B7.1 receptors on T cell surface, restores T cell activity, thus enhancing immune response and has potential to treat various types of tumors. Condition or disease Squamous Cell Carcinoma of the Head and Neck Drug: TQB2450+cisplatin or carboplatin + 5-Fluorouracil (5-FU) Drug: placebo+cisplatin or carboplatin + 5-Fluorouracil (5-FU) Phase 3 Study Design Go to
Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment Official Title: Multicenter, Randomized, Double-blind, Phase Ⅲ Clinical Study to Evaluate the Efficacy and Safety of TQB2450 Plus Chemotherapy(Cisplatin or Carboplatin+ 5-Fluorouracil (5-FU) ) Versus Placebo Plus Chemotherapy as First-Line Treatment in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma(R/M SCCHN) Estimated Study Start Date : Arms and Interventions Go to
Experimental: TQB2450+cisplatin or carboplatin + 5-Fluorouracil (5-FU) Drug: TQB2450+cisplatin or carboplatin + 5-Fluorouracil (5-FU) TQB2450 1200mg IV ,cisplatin 75 mg/m^2 IV or carboplatin AUC 5 IV on Day 1 of each week in 3-week cycles (6 cycle maximum); plus 5-FU 750 mg/m^2/day IV continuous from Day 1-5 of each 3- week cycle (6 cycle maximum). Placebo Comparator: placebo+cisplatin or carboplatin + 5-Fluorouracil (5-FU) Drug: placebo+cisplatin or carboplatin + 5-Fluorouracil (5-FU) placebo 1200mg IV ,cisplatin 75 mg/m^2 IV or carboplatin AUC 5 IV on Day 1 of each week in 3-week cycles (6 cycle maximum); plus 5-FU 750 mg/m^2/day IV continuous from Day 1-5 of each 3- week cycle (6 cycle maximum). Outcome Measures Go to OS [ Time Frame: up to 72 weeks ] Overall survival DOR [ Time Frame: up to 72 weeks ] Duration of Response PFS [ Time Frame: up to 24 weeks ] Progression-free survival DCR [ Time Frame: up to 24 weeks ] Disease Control Rate Eligibility Criteria Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Information from the National Library of Medicine
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Criteria Inclusion Criteria: Histologically- or cytologically-confirmed head and neck squamous cell carcinoma ,Primary tumor locations of oropharynx, oral cavity, hypopharynx, or larynx. No indications of local radical therapy for recurrence/metastasis head and neck squamous cell carcinoma. At least one measurable lesion( based on RECIST1.1). Can provide tissue for PD-L1 biomarker analysis: A newly obtained biopsy is preferred but an archival sample is acceptable. Tumors express PD-L1,and PD-L1 expression on at least 1% of tumour cells . 18 years and older. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1. Life expectancy of at least 3 months. “9.The main organs function are normally, the following criteria are met: routine blood tests:hemoglobin(Hb)≥90g/L(no blood transfusion and blood products within 14 days);absolute neutrophil count(ANC)≥1.5×109/L; platelets(PLT)≥100×109/L. Blood biochemical examination: alanine transaminase(ALT)and aspartate aminotransferase(AST)≤2.5×upper limit of normal (ULN)(when the liver is invaded, ALT, and AST ≤5× upper limit of normal (ULN) ); total bilirubin (TBIL)≤1.5×upper limit of normal (ULN)(Gilbert syndrome patients,≤3×upper limit of normal (ULN)); calculated creatinine clearance(CrCl)≥60mL/min(Creatinine clearance criteria for subjects treated with cisplatin)or CrCl≥50mL/min(Creatinine clearance criteria for subjects treated with carboplatin)(Application of Standard Cockcroft-Gault Formula). Coagulation function: activated partial thromboplastin time (aPTT) 、 international normalized ratio (INR) 、prothrombin time(PT)≤ 1.5×upper limit of normal (ULN). left ventricular ejection fraction (LVEF) measured by the Cardiac echocardiography greater than or equal to 50%.” 10. Male or female subjects should agree to use an adequate method of contraception starting with the first dose of study therapy through 6 months after the last dose of study(Such as intrauterine devices , birth control pills or condoms) ;Not Pregnant or breastfeeding women,Pregnancy before pregnancy screening(Within 7 days before the start of the study), the women who blood / urine results were positivetherapy. 11. Understood and Signed an informed consent form. Exclusion Criteria: – “1. Received systemic chemotherapy, but not chemotherapy for locally advanced disease as part of multimodality therapy (this treatment must be completed more than 6 months after informed consent). Note: chemotherapy for local advanced diseases includes induction chemotherapy, concurrent chemotherapy with radiotherapy and adjuvant chemotherapy.” 2. Has progressive disease (PD) within six (6) months of completion of curatively intended systemic treatment for locoregionally advanced HNSCC. 3. Prior therapy with an anti-programmed cell death (PD)-1, anti-PD-L1, anti-PD-L2, anti-tumor necrosis factor CD137, or anti-cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) antibody ,or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways. 4. Patients who have received cetuximab treatment within 6 mothss before randomization. 5. Diagnosed and/or treated additional malignancy within 5 years prior to randomization with the exception of cured carcinoma in situ of the cervix、intramucosal carcinoma of gastrointestinal tract、breast and non-melanoma skin cancers and superficial bladder tumors. 6.Known untreated central nervous system (CNS) metastases and/or carcinomatous meningitis. Participants with previously treated brain metastases may participate provided they are radiologically stable, clinically stable at least 2 weeks, there is no evidence of new or expanded brain metastasesand,and have not required steroids for at least 3 days prior to the first dose of study intervention.Stable brain metastases in this definition should be determined before the first administration of the study drug. Subjects with asymptomatic brain metastases (i.e., no neurological symptoms, no need for corticosteroids, and no lesion of > 1.5cm) can participate, but they need to have regular brain imaging examinations as the disease site). 7. Has neuropathy that is ≥ Grade 2 by Common Terminology Criteria for Adverse Events (CTCAE) version 5 criteria. 8. Previously had a severe hypersensitivity reaction to treatment with study drug or has a known sensitivity to any component of drug , including Severe hypersensitivity reaction≥3 grades (NCI CTCAEv5.0 )to monoclonal antibody 、fluorouracil、 carboplatin or cisplatin-related compounds. 9. Active autoimmune disease that may worsen with the administration of an immunostimulant. Patients with type 1 diabetes, vitiligo, psoriasis, or hypothyroidism or hyperthyroidism that do not require immunosuppression therapy are excluded. “10. Immunosuppressive drugs were used at randomization,except that: Intranasal, inhaled, topical steroid or topical steroid injection (e.g. intra-articular injection) Physiological doses of systemic corticosteroids (a dose of ≤ 10 mg daily prednisone (or equivalent) ) Preadministration of steroids for hypersensitivity reactions (e.g., preadministration of CT scans)” 11. Interstitial lung disease or non-contagious pneumonia (including past history and current illness); uncontrolled systemic diseases including diabetes, hypertension,acute lung disease, etc. except for radiotherapy-induced interstitial pneumonitis. 12. Has any other active infection requiring systemic therapy,including patients with active tuberculosis. 13. Unstable pleural effusion, pericardial effusion or ascites. 14. Significant cardiovascular diseases such as heart failure of New York Heart Academy(NYHA) Class 2 and above, myocardial infarction within the past 3 months, unstable arrhythmias (including QT interval ≥480 ms) or unstable Angina. 15. Patients with immunodeficiency, including HIV positive or other acquired, congenital immunodeficiency disease, or organ transplant history. “16. Virological examination of hepatitis B or hepatitis C during screening meets any of the following criteria: HBsAg positive and HBV DNA positive (≥1000 copies /mL); HCV antibody and HCV-RNA positive(The result is greater than the detection limit of the analytical method).” 17. Major surgery, or unhealed wounds, ulcers or fractures within 4 weeks before randomization. 18.Has received a live-virus vaccination within 4 weeks before randomization ,allowing received seasonal flu vaccines without live viruses. 19. Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks prior to the first dose of study intervention. 20. Investigator judges that the patient is not eligible to join the study. Contacts and Locations Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03855384 Contacts

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