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Corticosteroid-induced lipodystrophy is a condition of abnormal fat deposition caused by corticosteroid medications.[1] Fat accumulates in the facial area (“moon face”), dorsocervical region (“buffalo hump”), and abdominal area (“pot belly” or “beer belly”), whereas the thickness of subcutaneous fat in the limbs is decreased.[1] The resulting appearance has been described as “Cushingoid”,[1] in relation to the fact that it also occurs in individuals with Cushing’s syndrome.[2] The condition is considered by patients to be the most distressing side effect caused by corticosteroids.[1]

Short-term therapy (<3 months) with 10 to 30 mg/day of a prednisone equivalent has been reported to be associated with Cushingoid traits in 15 to 40%.[1] Long-term therapy (>3 months) with corticosteroids has been associated with Cushingoid features in 32 to 83% of individuals.[1] However, these symptoms have mostly been diagnosed in a subjective and observer-dependent manner.[1] In a prospective study, the cumulative incidence of corticosteroid-induced lipodystrophy with high-dose prednisone therapy was found to be 61% after 3 months, 65% after 6 months, 68% after 9 months, and 69% after 12 months.[1] One study found that even a very low dosage of prednisone of 5 mg/day was associated with symptoms of “Cushing’s syndrome”.[1] It has been said that data on risk factors for corticosteroid-induced lipodystrophy, such as corticosteroid dosage or duration of therapy, is surprisingly sparse.[1] Possible risk factors for corticosteroid-induced lipodystrophy include high residual cortisol secretion, decreased clearance of corticosteroids, female sex, younger age (<50 years), high initial body-mass index, and high caloric intake.[1]

Corticosteroid-induced lipodystrophy has been found to be usually reversible at prednisone-equivalent dosages of less than 10 mg/day.[1] A low-calorie diet may be considered to limit the risk of corticosteroid-induced lipodystrophy or to attempt to reverse it.[1] Corticosteroid-induced lipodystrophy is not merely an aesthetic adverse effect, as it has been associated with features of metabolic syndrome such as insulin resistance, dyslipidemia, and high blood pressure.[1]

See also[edit]

  • Steroid dementia syndrome
  • Steroid diabetes
  • Steroid-induced osteoporosis
  • Steroid induced skin atrophy

References[edit]

  • ^ a b c d e f g h i j k l m n Fardet L, Kassar A, Cabane J, Flahault A (2007). “Corticosteroid-induced adverse events in adults: frequency, screening and prevention”. Drug Saf. 30 (10): 861–81. doi:10.2165/00002018-200730100-00005. PMID 17867724..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:”””””””‘””‘”}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url(“//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png”)no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url(“//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png”)no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url(“//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png”)no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
  • ^ Pivonello R, Isidori AM, De Martino MC, Newell-Price J, Biller BM, Colao A (July 2016). “Complications of Cushing’s syndrome: state of the art”. Lancet Diabetes Endocrinol. 4 (7): 611–29. doi:10.1016/S2213-8587(16)00086-3. PMID 27177728.
  • Hypothalamic/
    pituitary axesThyroidParathyroidAdrenalGonads

    • ovarian: Polycystic ovary syndrome
    • Premature ovarian failure
    • testicular: enzymatic
      • 5α-reductase deficiency
      • 17β-hydroxysteroid dehydrogenase deficiency
      • aromatase excess syndrome
    • Androgen receptor (Androgen insensitivity syndrome)
    • general: Hypogonadism (Delayed puberty)
    • Hypergonadism
      • Precocious puberty
    • Hypoandrogenism
    • Hypoestrogenism
    • Hyperandrogenism
    • Hyperestrogenism
    • Postorgasmic illness syndrome

    Height

    • Dwarfism/Short stature
      • Midget
      • Laron syndrome
      • Psychosocial
      • Ateliosis
    • Gigantism

    Multiple

    • Autoimmune polyendocrine syndrome multiple
      • APS1
      • APS2
    • Carcinoid syndrome
    • Multiple endocrine neoplasia
      • 1
      • 2A
      • 2B
    • Progeria
      • Werner syndrome
      • Acrogeria
      • Metageria
    • Woodhouse–Sakati syndrome


    Source: https://en.wikipedia.org/wiki/Corticosteroid-induced_lipodystrophy

    Plaquenil Reviews

    <h1>Plaquenil Reviews</h1>

    Plaquenil Reviews

    Posted 12 months ago (11/10/2017) Rated Plaquenil for Rheumatoid Arthritis Report
    I took plaquenil for 6 months and other medications for 2 years for RA. I developed congestive heart failure and was taken off all RA meds except prednisone for a year. I went back to my rheumatologist and he prescribed plaquenil again. After taking it for 6 weeks, I had shortness of breath so I stopped taking it. After about a week I was able to breathe easier. No more plaquenil for me! Report Posted 34 months ago (1/21/2016) Rated Plaquenil for Systemic Lupus Erythematosus Report
    In the beginning ( The first year or two) It really helped, with my symptoms, with lupus. I noticed, I was getting a lot of infections. The longer, I have been on plaquenil. I have been on this drug, for about 10 yrs.. I have been experiencing several of the side effects. For years, I have been complaining to any of my doctors, who would listen, about the dizziness. This past two years, the dizziness has now, turned in to vertigo. Again, I have been trying to find out , what have been causing the vertigo. Now, that I have read this site, explanation of plaquenil, I think the mystery is solved. Years I have been doing my research on plaquenil, and all of it’s side effects, on different sites. A lot of the side effects have been repeated, but I don’t remembering seeing vertigo, which I have been complaining to all of my doctors about. None of them, including my rheumatologist, who was the one , who put me on plaquenil, could tell me why, I was experiencing vertigo. So I would like to give kudos, to the reseacher, of this site to give the information, I needed to confront my doctors with. I advise anyone taking this drug, to writing down your symptoms and compare it to the side effe Report About Drugs A-Z
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