Category Prednisone Side Effect

A Deadly Mistake Uncovered on Prednisone Taper and How to Avoid It

My side effects began to go away. Thus, some men and women turn 12 day prednisone taper side effects to them so as to acquire medication they otherwise wouldn’t have been in a position to purchase, which could possibly be a dangerous proposition. Side effects might be different in children, or occur rarely in comparison to adults taking the very same medication. Not only do you have to discover the ideal combination is effective for each distinctive individual, but in addition it takes a minumum of one month before you’ve given each and every medication its fair shot. Repeated use may lead to a rebound effect that can lead to even more headaches. Prophylactic use of different agents, including bisphosphonates could possibly be considered for some.

Pneumonia cases brought on by Varicella virus can be cured using the medication named Acyclovir. Joint problems can develop into a big long-term symptom. Long-term problems because of pauciarticular JRA are seen in a number of the children affected. Long term problems as a result of systemic JRA are very similar to polyarticular JRA. Then, this issue of steroid-sparing treatments started to surface with my care team. Be cautious about taking an excessive amount of tylenol since it can result in liver problems at high dosages.

Yes, if you do eventually quit taking Oxycontin, you will ought to be slowly tapered down in order to prevent withdrawal symptoms. Prednisone is really a miracle drug! It is part of a class of drugs called corticosteroids which also includes Methylprednisolone, and dexamethasone. Consult your medical care provider any questions that you might have about how to utilize Prednisone. While not valuable in all instances, it might be useful when methotrexate or gold haven’t been completely powerful and may be used alone or in combination with different drugs.

Due to their many side effects, glucocorticoids have to be employed with caution. They should never be stopped suddenly if they have been taken for more than a month. Corticosteroids might affect the blood glucose levels of diabetic patients. Used appropriately, they can greatly improve your pet’s quality of life while helping to treat serious illness. If you’ve been on steroids lots of times, then it could only have a couple of nights ahead of your sleep clock resets.

Based on which kind of allergy test is performed, you might want to discontinue your pet’s allergy medications for a period of time prior to the test. There’s a blood test you may take to keep tabs on your cortisol levels known as the cortrosyn stimulation test. Blood levels are often checked to ascertain the ideal dosage for your kid. The sodium levels begin to fall, while the potassium levels begin to rise. High potassium levels may have a detrimental influence on the heart and can cause circulatory collapse. The dosage requirements fluctuates based on the harshness of the attack.

Others, like myself, had ON when it was not so often called a symptom of potential MS, so my very first experience with Solu-Medrol was as the effect of a different kind of MS attack. Other symptoms may happen in the very first week of tapering and can endure up to 2 weeks. Try to remember, even caffeine can bring about withdrawal symptoms. A diagnosis of fibromyalgia does not necessarily mean that further tests aren’t required.

Patients with widespread aches and pains are often encountered in clinical practice, but the particular diagnosis can be hard to make because of the broad array of potential diseases that could be responsible. Hand washing is critical, but doctors forget their protocol is to steer clear of cross-infection for patients. Your health care provider might also think about prescribing a prednisone taper. Not every doctor will be the correct fit for your requirements, and that’s okay. Which means doctors only really wish to check your blood monthly or two. To be able to do so, you will need to understand a naturopathic doctor who knows about intestinal permeability.

The treatments mentioned previously should help to soothe the epidermis but it’s still true that you may want to apply a 1 percent hydrocortisone cream. It involves the use of bisphosphonate drugs. It involves the use of corticosteroids such as Prednisone. Treatments like surgery could be necessary for special long-term issues.

The dose ought to be increased in case the signs aren’t well controlled within one week. If it’s almost time for your next dose, skip the missed dose and return to your normal dosing schedule. Before you take your very first dose of Suboxone, you’ll be requested to remain clean for some length of time a long enough for you to begin feeling the initial effects of opiate withdrawal.

Consult your physician if it’s OK to raise your dosage until your steroid treatment is over. Medications may also make an impact on your child’s oral wellbeing and development. These medications might be employed to take care of children with arthritis and associated ailments. Oral steroid medication is ordinarily the main treatment for the disease.

Acute Lymphocytic Leukemia (ALL)

Acute Lymphocytic Leukemia (ALL)

Acute lymphocytic leukemia (ALL) is a fast-growing cancer of a type of white blood cells called lymphocytes. These cells are found in the bone marrow and other parts of the body. Acute lymphocytic leukemia (ALL) occurs when the body produces a lar…

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Drug effectiveness in reducing glucocorticoid-induced bone loss

Drug effectiveness in reducing glucocorticoid-induced bone loss

About one in every 100 people in the world takes glucocorticoids long term to treat immune-mediated diseases. However, glucocorticoids, such as prednisone, have a side effect — they induce glucocorticoid-induced bone loss, causing an estimated yearly bone fr…

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Fluticasone propionate

<h1>Fluticasone propionate</h1>

Fluticasone propionate belongs to a class of drugs known as corticosteroids, specifically glucocorticoids, which are hormones that predominantly affect the metabolism of carbohydrates and, to a lesser extent, fat and protein. It is used to treat asthma, allergic rhinitis, nasal polyps, various skin disorders and Crohn’s disease and ulcerative colitis. It is also used to treat eosinophilic esophagitis.


  • 1 Medical uses
  • 2 Adverse effects
    • 2.1 Nasal spray
    • 2.2 Oral inhaler
  • 3 Pharmacology
  • 4 Interactions
  • 5 See also
  • 6 References

Medical uses[edit]

Fluticasone is used by powder or aerosol inhalation for the prophylaxis of asthma, the nasal spray is used for prophylaxis and treatment of allergic rhinitis, nasal drops are used in the treatment of nasal polyps, and creams and ointments are applied topically in the treatment of various skin disorders. It can be given orally in the treatment of Crohn’s disease and ulcerative colitis. Some benefit was also reported in coeliac disease.[citation needed]

Adverse effects[edit]

If taken correctly, the nasal spray and oral inhaler formulation have fewer corticosteroid side effects than the tablet formulation because they limit systemic (blood) absorption.[1] However, the systemic absorption is not negligible even with correct administration.[1] Using the spray or inhaler at higher than recommended doses or with other corticosteroids can increase the risk for serious, systemic corticosteroid induced side effects.[1][2] These side effects include weakened immune system, increased risk of systemic infections, osteoporosis, and elevated pressure in the eyes.[3]

Nasal spray[edit]

Common side effects may include nasal irritation (burning, stinging, bleeding), headache, upset stomach (nausea, vomiting), and diarrhea. Rare side effects include infection (evidenced by, e.g., fever, sore throat, and cough), vision problems, severe swelling, hoarse voice, and difficulty breathing or swallowing.[4]

Oral inhaler[edit]

Common side effects may include upper respiratory tract infection, throat irritation, thrush, cough, and headache. Rare side effects include bruising, swelling of the face/neck, depression, tiredness, and shortness of breath.[5]


Fluticasone propionate is a highly selective agonist at the glucocorticoid receptor with negligible activity at androgen, estrogen, or mineralocorticoid receptors, thereby producing anti-inflammatory and vasoconstriction effects. It has been shown to have a wide range of inhibitory effects on multiple cell types (e.g. mast cell, eosinophil, neutrophil, macrophages, and lymphocytes) and mediators (e.g. histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation. Fluticasone propionate is stated to exert a topical effect on the lungs without significant systemic effects at usual doses, due to its low systemic bioavailability.


Fluticasone propionate is broken down by CYP3A4 (Cytochrome P450 3A4), and has been shown to interact with strong CYP3A4 inhibitors such as ritonavir and ketoconazole.[1][2]

Ritonavir is a common drug used in the treatment of HIV. Coadministration of ritonavir and fluticasone may lead to increased levels of fluticasone in the body, which may lead to Cushing’s Syndrome and adrenal insufficiency.[6]

Ketoconazole, an antifungal drug, has also been shown to increase fluticasone concentration leading to systemic corticosteroid side effects.[1][2]

See also[edit]

  • Fluticasone furoate
  • Glucocorticoid


  • ^ a b c d e Flonase[package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2003.
  • ^ a b c Flovent[package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2014
  • ^ “Prednisone and other corticosteroids: Balance the risks and benefits”. Retrieved 4 March 2018. 
  • ^ AHFS Consumer Medication Information [Internet]. Bethesda (MD): American Society of Health-System Pharmacists, Inc.; ©2008. Fluticasone Nasal Spray; [revised 2010 Sept 1; reviewed 2010 Sept 1; cited 2014 Nov 2]; [about 1 p.]. Available from:
  • ^ AHFS Consumer Medication Information [Internet]. Bethesda (MD): American Society of Health-System Pharmacists, Inc.; ©2008. Fluticasone Oral Inhalation; [revised 2010 Sept 1; reviewed 2010 Sept 1; cited 2014 Nov 2]; [about 1 p.]. Available from:
  • ^ Foisy, M., Yakiwchuk, E., Chiu, I. and Singh, A. (2008), Adrenal suppression and Cushing’s syndrome secondary to an interaction between ritonavir and fluticasone: a review of the literature. HIV Medicine, 9: 389–396. doi: 10.1111/j.1468-1293.2008.00579.x
  • Antiglucocorticoids

    • Antagonists: Aglepristone
    • Ketoconazole
    • Mifepristone
    • Ulipristal acetate

    Synthesis modifiers

    • Acetoxolone
    • Aminoglutethimide
    • Carbenoxolone
    • Enoxolone
    • Ketoconazole
    • Metyrapone
    • Mitotane
    • Trilostane
    • #WHO-EM
    • ‡Withdrawn from market
    • Clinical trials:
      • †Phase III
      • §Never to phase III

    See also
    Glucocorticoid receptor modulators
    Mineralocorticoids and antimineralocorticoids
    List of corticosteroids

    Systemic use:

    • Phenylephrine
    • Phenylpropanolamine
    • Pseudoephedrine (+loratadine)


    • Beclometasone#
    • Betamethasone
    • Budesonide
    • Ciclesonide
    • Flunisolide
    • Fluticasone
    • Mometasone
    • Triamcinolone

    muscarinic antagonist

    • Aclidinium bromide
    • Glycopyrronium bromide
    • Ipratropium bromide#
    • Oxitropium bromide
    • Tiotropium bromide
    • Umeclidinium bromide

    Mast cell stabilizers

    • Cromoglicate
    • Nedocromil


    • Acefylline
    • Ambuphylline
    • Bamifylline
    • Doxofylline
    • Enprofylline
    • Etamiphylline
    • Proxyphylline
    • Theophylline/Aminophylline/Choline theophyllinate

    Eicosanoid inhibition


    • Amlexanox
    • Eprozinol
    • Fenspiride
    • Omalizumab

    Combination products

    • Aclidinium/formoterol
    • Beclometasone/formoterol
    • Beclometasone/formoterol/glycopyrronium
    • Budesonide/formoterol
    • Fluticasone furoate/vilanterol
    • Fluticasone propionate/salmeterol
    • Indacaterol/glycopyrronium bromide
    • Ipratropium bromide/salbutamol
    • Mometasone/formoterol
    • Umeclidinium bromide/vilanterol
    • #WHO-EM
    • ‡Withdrawn from market
    • Clinical trials:
      • †Phase III
      • §Never to phase III

    See also
    Receptor/signaling modulators
    Glucocorticoids and antiglucocorticoids
    Mineralocorticoid receptor modulators
    List of corticosteroids


    Fraud, Deceptions, and Downright Lies About Prednisone And Alcohol Exposed

    As stated above, prednisone is among the most productive drugs offered in the marketplace and used for the treatment of autoimmune disorders. At the same time, it is one of the crucial drugs used in treatment of certain types of cancer like the non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, etc.. It belongs to the family of corticosteroid drugs, and is similar to the hormone cortisol produced by the adrenal glands. It comes under the category of drugs called corticosteroids. It is one of the most effective drugs available in the market today. It is one of the most commonly prescribed synthetic glucocorticoid drugs. Along with weight gain, it can cause osteoporosis by accelerating the process of bone loss.

    Prednisone isn’t an exception. It needs to be discontinued gradually. It is primarily a steroid and so, it does have both positive as well as negative effects on our health. It is a type of steroid that helps restore immunity levels, which malfunction as a result of illness or injury. It is a very helpful and strong steroid which is used in treating numerous diseases. In short, it must not be taken without the prescription of a doctor. The synthetic hormone prednisone is utilized to take care of quite a few ailments.

    Make certain you ask your physician before giving your child prednisone, since the dosage varies in line with the essence of the ailment. After examining the size of the goiter, the physician will decide whether it is imperative to begin the therapy. So it is highly advisable to talk about with your physician and understand more concerning the surgery.

    The effects may change from person to person. The side effects can stay for a brief time period, though some side effects are long-term. Elderly individuals will get the majority of the side results. In some instances, the side effects of prednisone can end up being life-threatening.

    Life, Death and Prednisone And Alcohol

    In instance, you create any withdrawal symptoms, get in touch with your doctor immediately, for prednisone withdrawal therapy. It is essential that you don’t ignore symptoms that could hint at a critical health issue. The childhood rheumatism symptoms are absolutely evident and they’re mentioned below. The seriousness of the side effects is dependent upon the dosage, together with the amount of time for which it is taken. In any case, if your symptoms have ceased, it’s no indication you might start the usage of alcohol all over again. Foamy urine symptoms are among the indicators of UTI and is chiefly accompanied by burning sensation.

    Rumors, Lies and Prednisone And Alcohol

    Corticosteroids are among the best types of medicine. They are effectively used to control the symptoms. In some instances, steroids like mathylprednisolone and prednisone are provided to the patients, either orally or intravenously, that might increase the likelihood of a fast recovery. Usually, they are prescribed when the use of other drugs are not giving the desired results. Steroids (prednisone) and antivirals (for example, acyclovir) usually have little if any benefit.

    The Argument About Prednisone And Alcohol

    The dosage of the drug must be increased, or a different corticosteroid drug has to be prescribed to control the signs of the problem. It may be higher for serious conditions such as asthma or nephrotic syndrome. In such situations, delivering the appropriate dosage under strict medical supervision is necessary for minimizing the adverse results. The dose is often adjusted taking under consideration the reply to the therapy. Lowering the dose of prednisone gradually enables the adrenal glands to recuperate slowly. Hence, it must be mentioned that before beginning to take prednisone dosage, or making any sort of modifications to the present dosage, taking an opinion of your physician is extremely important.

    The New Angle On Prednisone And Alcohol Just Released

    The drug must be taken under medical supervision. From time to time, it may be due to certain drugs. Drugs like anti-inflammatory corticosteroid medication prednisone assists in managing muscle deterioration. In any case, consuming alcohol together with prednisone also is dependent on your general well-being and tolerance levels.

    A Review of Drugs

    Somebody who has overdosed on drugs, for instance, could be obtunded but equipped to communicate. Although they can be very effective at doing that, there can be serious side effects. They usually only deepen the issue. Discontinuing the drug results in withdrawal symptoms that depend on the kind of drug used. Generic drugs work in the exact same way and in the same quantity of time as brand-name drugs.

    Generally medications aren’t recommended because maintenance and efficient use of prescriptions given to multiple personality states is challenging to attain. If you’re taking a medication of any sort and are impotent, consult your doctor or pharmacist to ascertain whether the drug could be responsible. So in both situations, reviewing and adjusting medication may be one of the absolute most productive approaches for controlling them. If you’re on a medication for osteoporosis, once balance is accomplished, speak with your physician to get off prescriptions. Most medications have the once-a-day selection, but your physician will tailor your prescription to your requirements. Anti-seizure medications including Neurontin may help lessen the incidence of tremors.

    The drug can result in jaw-clenching, decreased appetite, higher blood pressure, and a higher pulse. Drugs are in ugly escape from reality that provides the user an invincible feeling for a brief period of time. It is simple for a person to rationalize employing a drug because it came from a health care provider.

    When it has to do with alcohol and drug addictions, Social Security has completely altered the system in the previous decade or so. Ask whoever has tried drugs and they are going to tell you that it is among the best feelings of their life. Drugs are produced in huge quantities on the black industry. Drugs like Thorazine for example are utilised to diminish psychotic symptoms like delusions and hallucinations.

    The Nuiances of Drugs

    The doctors will guide you for the length of time you must continue the intake of the prescribed medicines and should you act accordingly then you may become absolutely satisfactory outcomes. They will first diagnose the actual trouble of the victims and then on the basis of that perfect medicines will be prescribed. If your physician prescribes too high of a Myospaz dosage or whether you take more than the advised amount of the drug, it’s possible to create side effects as a result of overdose. The physician would have the capacity to allow you to know that grapefruit has been demonstrated to interfere with a few enzymes that break down certain drugs in our intestines and liver, increasing blood levels of the drug that could result in a greater chance of serious side results. Other forms of doctors don’t have that alternative.

    Drugs are much simpler to produce and to smuggle. Either way, they have to explain a significant fraction. Most drugs do a fantastic job of taking reality from the minds of the user.

    Just because somebody you know has not lost everything he or she owns to drugs does not need to mean which he or she doesn’t have a drug addiction issue. There’s, clearly, a reason folks become hooked on drugs. Every drug has its own particular half life which may be used to learn whether an individual has ingested the substance recently. As an example, using or selling drugs would probably create a denial. People today figure whether a drug is prescribed by a physician, it has to be ok. Once a drug is approved, the significant portion of the cost was absorbed. All chemotherapy drugs utilized in the United States of America have been accepted by the FDA.

    Alcohol has a potent effect on your entire body and on your sexual reaction. If a person feels they need to consume larger quantities of alcohol as a way to feel good, that individual is probably an alcoholic. Though the majority of people can consume alcohol when taking cephalexin, in some individuals there might be side results. It’s also important to not forget that some cold medications contain alcohol. As teenagers and young adults, it’s very simple to believe that drug and alcohol use can be dealt with and controlled, especially should they see others they know doing something similar.

    Alcoholism exists every time an individual has a robust or uncontrollable want for alcohol and cannot drink a quantity of alcohol that’s enough. Alcoholism and depression frequently go together, resulting in a very very good probability of alcohol-antidepressant interactions. Alcohol addiction is virtually as simple to develop for much the exact same reason. To summarize, there are numerous drug addiction signs out there. It is a serious disorder. It is multi-layered and has a variety of causes as well as contributing factors. The very first step towards combating drug addiction is to earn the abuser mindful of the damage it results in the body.

    Surprisingly, addicts are a few of their very best informants. Most addicts lack confidence and has to be taught to be a master of the circumstance and not a slave to addiction. Many drug addicts don’t have anybody to lean on and that may make it challenging to find the motivation each day to keep away from their chemical security blanket.

    The Do’s and Don’ts of Prednisone For Poison Ivy

    The Upside to Prednisone For Poison Ivy

    Prednisone has to be discontinued gradually. It is produced by dehydrogenation of cortisone. It is no exception. It is primarily a steroid and so, it does have both positive as well as negative effects on our health. As mentioned above, it is recommended when the body is not in a state to produce enough glucocorticoids itself. In short, it must not be taken without the prescription of a doctor. The synthetic hormone prednisone is utilized to take care of quite a few ailments.

    Prednisone can occasionally be affiliated with certain kinds of side results. Specifically, prednisone taken orally has been demonstrated to be the most effect approach to attain some comfort from the immune reaction to poison ivy. Owing to the fact that it might have good as well as bad effects on the human body, a proper set of guidelines provided by an expert must be followed while discontinuing the use of the same. It is a popular drug recommended by doctors for treating a wide range of medical conditions. An individual must remember that while prednisone definitely does give rise to a lot of side effects, it’s additionally a life-saving drug. If you’re using prednisone for poison ivy then it is possible to face several side effects because it’s an incredibly powerful medication. If you’re using prednisone for poison ivy then you ought to use a lower dose.

    As stated above, prednisone is among the absolute most productive drugs offered in the marketplace and used for the treatment of autoimmune disorders. At the same time, it is one of the crucial drugs used in treatment of certain types of cancer like the non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, etc.. It belongs to the family of corticosteroid drugs, and is similar to the hormone cortisol produced by the adrenal glands. It comes under the category of drugs called corticosteroids. It is one of the most effective drugs available in the market today. It is one of the most commonly prescribed synthetic glucocorticoid drugs. Along with weight gain, it can cause osteoporosis by accelerating the process of bone loss.

    Prednisone For Poison Ivy Features

    If In the event you do miss a dose, take it whenever possible. The doses would need to be increased for a brief period followed by gradual decrease in dosage. Lowering the dose of prednisone gradually assists the adrenal glands to recuperate slowly. Make sure that you do not miss any dose. If it is nearly time for your next dose, skip the missed dose and return to your normal dosing schedule. In case of an acute flare-up of the disease procedure, it can be essential to return to a whole suppressive daily divided corticoid dose for control.

    The Birth of Prednisone For Poison Ivy

    The leaves from a poison ivy plant isn’t going to enable you to find a rash. Unfortunately, poison ivy can be exceedingly unbearable occasionally. For diabetes patients, however, it’s sensible to steer clear of poison ivy at any cost. Poison ivy is a shrub-type plant that’s widely spread and found in practically all parts on earth. Poison ivy isn’t contagious although the rashes seem red and full of blisters often are shunned by men and women. About five milligrams of prednisone can make an effect like that created by the human body’s daily output of cortisol.

    Ruthless Prednisone For Poison Ivy Strategies Exploited

    Prednisone treatment may not be stopped abruptly. Generally, it begins with a high dose which is gradually reduced over a period of few weeks. Getting treatment for poison ivy will produce the patient comfortable in addition to reduce the likelihood of skin infection. Poison ivy treatments are usually restricted to self-care approaches. The drug needs to be taken under medical supervision. To prevent adverse effects, one ought to select the drug in the prescribed dosage. In any case, consuming alcohol together with prednisone also is dependent on your general well-being and tolerance levels.

    There is an excellent chance they’ll provide you the crucial meds to control the poison ivy and eventually remove it. The exposure to poison ivy is particularly increased during the summertime because people spend much more time outdoors indulging in numerous unique kinds of activities like trekking and hiking. In some instances, the side effects of prednisone can end up being life-threatening. It’s further imperative to comprehend the side effects of drugs, particularly when they should be given to children. Although the affected folks experience such side effects, tapering is the sole way which will help prevent the effects of sudden discontinuation of the medicine that could end up being fatal. Also, prednisone and alcohol reactions can differ in the instance of unique drugs. Also, list questions you want to ask your physician about your poison ivy rash.

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    Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.[1]

    Some common naturally occurring steroid hormones are cortisol (C
    5), corticosterone (C
    4), cortisone (C
    5) and aldosterone (C
    5). (Note that aldosterone and cortisone share the same chemical formula but the structures are different.) The main corticosteroids produced by the adrenal cortex are cortisol and aldosterone.[2]


    • 1 Classes
    • 2 Medical uses
    • 3 Pharmacogenetics
      • 3.1 Asthma
    • 4 Adverse effects
    • 5 Biosynthesis
    • 6 Classification
      • 6.1 By chemical structure
        • 6.1.1 Group A – Hydrocortisone type
        • 6.1.2 Group B – Acetonides (and related substances)
        • 6.1.3 Group C – Betamethasone type
        • 6.1.4 Group D – Esters
          • Group D1 – Halogenated (less labile)
          • Group D2 – Labile prodrug esters
      • 6.2 By route of administration
        • 6.2.1 Topical steroids
        • 6.2.2 Inhaled steroids
        • 6.2.3 Oral forms
        • 6.2.4 Systemic forms
    • 7 History
      • 7.1 Etymology
    • 8 See also
    • 9 References






    • Glucocorticoids such as cortisol affect carbohydrate, fat, and protein metabolism, and have anti-inflammatory, immunosuppressive, anti-proliferative, and vasoconstrictive effects.[3] Anti-inflammatory effects are mediated by blocking the action of inflammatory mediators (transrepression) and inducing anti-inflammatory mediators (transactivation).[3] Immunosuppressive effects are mediated by suppressing delayed hypersensitivity reactions by direct action on T-lymphocytes.[3] Anti-proliferative effects are mediated by inhibition of DNA synthesis and epidermal cell turnover.[3] Vasoconstrictive effects are mediated by inhibiting the action of inflammatory mediators such as histidine.[3]
    • Mineralocorticoids such as aldosterone are primarily involved in the regulation of electrolyte and water balance by modulating ion transport in the epithelial cells of the renal tubules of the kidney.[3]

    Medical uses[edit]

    Synthetic pharmaceutical drugs with corticosteroid-like effects are used in a variety of conditions, ranging from brain tumors to skin diseases. Dexamethasone and its derivatives are almost pure glucocorticoids, while prednisone and its derivatives have some mineralocorticoid action in addition to the glucocorticoid effect. Fludrocortisone (Florinef) is a synthetic mineralocorticoid. Hydrocortisone (cortisol) is typically used for replacement therapy, e.g. for adrenal insufficiency and congenital adrenal hyperplasia.

    Medical conditions treated with systemic corticosteroids:[3][4]

    • Allergy and respirology medicine
      • Asthma (severe exacerbations)
      • Chronic obstructive pulmonary disease (COPD)
      • Allergic rhinitis
      • Atopic dermatitis
      • Hives
      • Angioedema
      • Anaphylaxis
      • Food allergies
      • Drug allergies
      • Nasal polyps
      • Hypersensitivity pneumonitis
      • Sarcoidosis
      • Eosinophilic pneumonia
      • Some other types of pneumonia (in addition to the traditional antibiotic treatment protocols)
      • Interstitial lung disease
    • Dermatology
      • Pemphigus vulgaris
      • Contact dermatitis
    • Endocrinology (usually at physiologic doses)
      • Addison’s Disease
      • Adrenal insufficiency
      • Congenital adrenal hyperplasia
    • Gastroenterology
      • Ulcerative colitis
      • Crohn’s disease
      • Autoimmune hepatitis
    • Hematology
      • Lymphoma
      • Leukemia
      • Hemolytic anemia
      • Idiopathic thrombocytopenic purpura
      • Multiple Myeloma
    • Rheumatology/Immunology
      • Rheumatoid arthritiseas
      • Systemic lupus erythematosus
      • Polymyalgia rheumatica
      • Polymyositis
      • Dermatomyositis
      • Polyarteritis
      • Vasculitis
    • Ophthalmology
      • Uveitis
      • Keratoconjunctivitis
    • Other conditions
      • Multiple sclerosis
      • Organ transplantation
      • Nephrotic syndrome
      • Chronic hepatitis (flare ups)
      • Cerebral edema
      • IgG4-related disease
      • Prostate cancer
      • Tendinosis
      • Lichen planus

    Topical formulations are also available for the skin, eyes (uveitis), lungs (asthma), nose (rhinitis), and bowels. Corticosteroids are also used supportively to prevent nausea, often in combination with 5-HT3 antagonists (e.g. ondansetron).

    Typical undesired effects of glucocorticoids present quite uniformly as drug-induced Cushing’s syndrome. Typical mineralocorticoid side-effects are hypertension (abnormally high blood pressure), hypokalemia (low potassium levels in the blood), hypernatremia (high sodium levels in the blood) without causing peripheral edema, metabolic alkalosis and connective tissue weakness.[5] Wound healing or ulcer formation may be inhibited by the immunosuppressive effects.

    Clinical and experimental evidence indicates that corticosteroids can cause permanent eye damage by inducing central serous retinopathy (CSR, also known as central serous chorioretinopathy, CSC).[6] A variety of steroid medications, from anti-allergy nasal sprays (Nasonex, Flonase) to topical skin creams, to eye drops (Tobradex), to prednisone have been implicated in the development of CSR.[7][8]

    Corticosteroids have been widely used in treating people with traumatic brain injury.[9] A systematic review identified 20 randomised controlled trials and included 12,303 participants, then compared patients who received corticosteroids with patients who received no treatment. The authors recommended people with traumatic head injury should not be routinely treated with corticosteroids.[10]



    Patients’ response to inhaled corticosteroids has some basis in genetic variations. Two genes of interest are CHRH1 (corticotropin-releasing hormone receptor 1) and TBX21 (transcription factor T-bet). Both genes display some degree of polymorphic variation in humans, which may explain how some patients respond better to inhaled corticosteroid therapy than others.[11][12]

    Adverse effects[edit]

    Lower arm of a 47-year-old female showing skin damage caused by topical corticosteroid use.

    Use of corticosteroids has numerous side-effects, some of which may be severe:

    • Severe amebic colitis: Fulminant amebic colitis is associated with high case fatality and can occur in patients infected with the parasite Entamoeba histolytica after exposure to corticosteroid medications [13].
    • Neuropsychiatric: steroid psychosis,[14] and anxiety,[15] depression. Therapeutic doses may cause a feeling of artificial well-being (“steroid euphoria”).[16] The neuropsychiatric effects are partly mediated by sensitization of the body to the actions of adrenaline. Therapeutically, the bulk of corticosteroid dose is given in the morning to mimic the body’s diurnal rhythm; if given at night, the feeling of being energized will interfere with sleep. An extensive review is provided by Flores and Gumina.[17]
    • Cardiovascular: Corticosteroids can cause sodium retention through a direct action on the kidney, in a manner analogous to the mineralocorticoid aldosterone. This can result in fluid retention and hypertension.
    • Metabolic: Corticosteroids cause a movement of body fat to the face and torso, resulting respectively in “moon face” and “buffalo hump”. and away from the limbs. Due to the diversion of amino-acids to glucose, they are considered anti-anabolic, and long term therapy can cause muscle wasting[18]
    • Endocrine: By increasing the production of glucose from amino-acid breakdown and opposing the action of insulin, corticosteroids can cause hyperglycemia,[19] insulin resistance and diabetes mellitus.[20]
    • Skeletal: Steroid-induced osteoporosis may be a side-effect of long-term corticosteroid use. Use of inhaled corticosteroids among children with asthma may result in decreased height.[21]
    • Gastro-intestinal: While cases of colitis have been reported, corticosteroids are often prescribed when the colitis, although due to suppression of the immune response to pathogens, should be considered only after ruling out infection or microbe/fungal overgrowth in the gastrointestinal tract. While the evidence for corticosteroids causing peptic ulceration is relatively poor except for high doses taken for over a month,[22] the majority of doctors as of 2010[update] still believe this is the case, and would consider protective prophylactic measures.[23]
    • Eyes: chronic use may predispose to cataract and retinopathy.
    • Vulnerability to infection: By suppressing immune reactions (which is one of the main reasons for their use in allergies), steroids may cause infections to flare up, notably candidiasis.[24]
    • Pregnancy: Corticosteroids have a low but significant teratogenic effect, causing a few birth defects per 1,000 pregnant women treated. Corticosteroids are therefore contraindicated in pregnancy.[25]
    • Habituation: Topical steroid addiction (TSA) has been reported in long-term users of topical steroids (users who applied topical steroids to their skin over a period of weeks, months, or years).[26][27] TSA is characterised by uncontrollable, spreading dermatitis and worsening skin inflammation which requires a stronger topical steroid to get the same result as the first prescription. When topical steroid medication is lost, the skin experiences redness, burning, itching, hot skin, swelling, and/or oozing for a length of time. This is also called ‘red skin syndrome’ or ‘topical steroid withdrawal'(TSW). After the withdrawal period is over the atopic dermatitis can cease or is less severe than it was before.[28]
    • In children the short term use of steroids by mouth increases the risk of vomiting, behavioral changes, and sleeping problems.[29]


    Steroidogenesis, including corticosteroid biosynthesis.

    The corticosteroids are synthesized from cholesterol within the adrenal cortex.[1] Most steroidogenic reactions are catalysed by enzymes of the cytochrome P450 family. They are located within the mitochondria and require adrenodoxin as a cofactor (except 21-hydroxylase and 17α-hydroxylase).

    Aldosterone and corticosterone share the first part of their biosynthetic pathway. The last part is mediated either by the aldosterone synthase (for aldosterone) or by the 11β-hydroxylase (for corticosterone). These enzymes are nearly identical (they share 11β-hydroxylation and 18-hydroxylation functions), but aldosterone synthase is also able to perform an 18-oxidation. Moreover, aldosterone synthase is found within the zona glomerulosa at the outer edge of the adrenal cortex; 11β-hydroxylase is found in the zona fasciculata and zona glomerulosa.


    By chemical structure[edit]

    In general, corticosteroids are grouped into four classes, based on chemical structure. Allergic reactions to one member of a class typically indicate an intolerance of all members of the class. This is known as the “Coopman classification”.[30][31]

    The highlighted steroids are often used in the screening of allergies to topical steroids.[32]

    Group A – Hydrocortisone type[edit]

    Hydrocortisone, methylprednisolone, prednisolone, prednisone, and triamcinolone (short- to medium-acting glucocorticoids).

    Group B – Acetonides (and related substances)[edit]

    Amcinonide, budesonide, desonide, fluocinolone acetonide, fluocinonide, halcinonide, and triamcinolone acetonide.

    Group C – Betamethasone type[edit]

    Beclometasone, betamethasone, dexamethasone, fluocortolone, halometasone, and mometasone.

    Group D – Esters[edit]
    Group D1 – Halogenated (less labile)[edit]

    Alclometasone dipropionate, betamethasone dipropionate, betamethasone valerate, clobetasol propionate, clobetasone butyrate, fluprednidene acetate, and mometasone furoate.

    Group D2 – Labile prodrug esters[edit]

    Ciclesonide, cortisone acetate, hydrocortisone aceponate, hydrocortisone acetate, hydrocortisone buteprate, hydrocortisone butyrate, hydrocortisone valerate, prednicarbate, and tixocortol pivalate.

    By route of administration[edit]

    Topical steroids[edit]
    Main article: Topical steroid

    For use topically on the skin, eye, and mucous membranes.

    Topical corticosteroids are divided in potency classes I to IV in most countries (A to D in Japan). Seven categories are used in the United States to determine the level of potency of any given topical corticosteroid.

    Inhaled steroids[edit]

    For nasal mucosa, sinuses, bronchii, and lungs.[33] This group includes:

    • Flunisolide[34]
    • Fluticasone furoate[34]
    • Fluticasone propionate[34]
    • Triamcinolone acetonide[34]
    • Beclomethasone dipropionate[34]
    • Budesonide[34]

    There also exist certain combination preparations such as Advair Diskus in the United States, containing fluticasone propionate and salmeterol (a long-acting bronchodilator), and Symbicort, containing budesonide and formoterol fumarate dihydrate (another long-acting bronchodilator)[34]. They are both approved for use in children over 12 years old.

    Oral forms[edit]

    Such as prednisone, prednisolone, methylprednisolone, or dexamethasone.[35]

    Systemic forms[edit]

    Available in injectables for intravenous and parenteral routes.[35]


    Tadeusz Reichstein, Edward Calvin Kendall. and Philip Showalter Hench were awarded the Nobel Prize for Physiology and Medicine in 1950 for their work on hormones of the adrenal cortex, which culminated in the isolation of cortisone.[41]

    Initially hailed as a miracle cure and liberally prescribed during the 1950s, steroid treatment brought about adverse events of such a magnitude that the next major category of anti-inflammatory drugs, the nonsteroidal anti-inflammatory drugs (NSAIDs), was so named in order to demarcate from the opprobrium.[42] Corticosteroids were voted Allergen of the Year in 2005 by the American Contact Dermatitis Society.[43]

    Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a 36-step process that started with deoxycholic acid, which was extracted from ox bile.[44] The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker, at Syntex, discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams. His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception.[45]

    In 1952, D.H. Peterson and H.C. Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone.[46] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $0.46 per gram by 1980. Percy Julian’s research also aided progress in the field.[47] The exact nature of cortisone’s anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.


    The cortico- part of the name refers to the adrenal cortex, which makes these steroid hormones. Thus a corticosteroid is a “cortex steroid”.

    See also[edit]

    • List of corticosteroids
    • List of corticosteroid cyclic ketals
    • List of corticosteroid esters
    • List of steroid abbreviations


  • ^ a b Nussey, S.; Whitehead, S. (2001). Endocrinology: An Integrated Approach. Oxford: BIOS Scientific Publishers. 
  • ^ Nussey, Stephen; Whitehead, Saffron (2001-01-01). The adrenal gland. BIOS Scientific Publishers. 
  • ^ a b c d e f g Liu, Dora; Ahmet, Alexandra; Ward, Leanne; Krishnamoorthy, Preetha; Mandelcorn, Efrem D; Leigh, Richard; Brown, Jacques P; Cohen, Albert; Kim, Harold (2013-08-15). “A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy”. Allergy, Asthma, and Clinical Immunology. 9 (1): 30. doi:10.1186/1710-1492-9-30. ISSN 1710-1484. PMC 3765115 . PMID 23947590. 
  • ^ Mohamadi, Amin; Chan, Jimmy J.; Claessen, Femke M. A. P.; Ring, David; Chen, Neal C. (2017-01-01). “Corticosteroid Injections Give Small and Transient Pain Relief in Rotator Cuff Tendinosis: A Meta-analysis”. Clinical Orthopaedics and Related Research. 475 (1): 232–243. doi:10.1007/s11999-016-5002-1. ISSN 0009-921X. PMC 5174041 . PMID 27469590. 
  • ^ Werner R (2005). A massage therapist’s guide to Pathology (3rd ed.). Pennsylvania: Lippincott Williams & Wilkins. 
  • ^ Abouammoh, Marwan A. (2015). “Advances in the treatment of central serous chorioretinopathy”. Saudi Journal of Ophthalmology. 29 (4): 278–286. doi:10.1016/j.sjopt.2015.01.007. ISSN 1319-4534. PMC 4625218 . PMID 26586979. 
  • ^ Carvalho-Recchia, CA; Yannuzzi, LA; Negrão, S; Spaide, RF; Freund, KB; Rodriguez-Coleman, H; Lenharo, M; Iida, T (2002). “Corticosteroids and central serous chorioretinopathy”. Ophthalmology. 109 (10): 1834–7. doi:10.1016/S0161-6420(02)01117-X. PMID 12359603. 
  • ^ “The New York Times :: A Breathing Technique Offers Help for People With Asthma”. Retrieved 2012-11-30. 
  • ^ Alderson P, Roberts I. “Plain Language Summary”. Corticosteroids for acute traumatic brain injury. The Cochrane Collaboration. p. 2. 
  • ^ Alderson, P.; Roberts, I. (2005). Alderson, Phil, ed. “Corticosteroids for acute traumatic brain injury”. Cochrane Database Syst Rev (1): CD000196. doi:10.1002/14651858.CD000196.pub2. PMID 15674869. 
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  • ^ Swinburn CR, Wakefield JM, Newman SP, Jones PW (December 1988). “Evidence of prednisolone induced mood change (‘steroid euphoria’) in patients with chronic obstructive airways disease”. Br J Clin Pharmacol. 26 (6): 709–713. doi:10.1111/j.1365-2125.1988.tb05309.x. PMC 1386585 . PMID 3242575. 
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  • ^ Martínek J, Hlavova K, Zavada F, et al. (June 2010). “”A surviving myth” —corticosteroids are still considered ulcerogenic by a majority of physicians”. Scand J Gastroenterol. 45 (10): 1156–61. doi:10.3109/00365521.2010.497935. PMID 20569095. 
  • ^ Fukushima, C.; Matsuse, H.; Tomari, S.; Obase, Y.; Miyazaki, Y.; Shimoda, T.; Kohno, S. (2003). “Oral candidiasis associated with inhaled corticosteroid use: Comparison of fluticasone and beclomethasone”. Annals of Allergy, Asthma & Immunology. 90 (6): 646–651. doi:10.1016/S1081-1206(10)61870-4. PMID 12839324. 
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  • Sex steroids


    • Cholestanes: 24S-Hydroxycholesterol
    • Cholesterol
    • Pregnanes: 3α-Dihydroprogesterone
    • 3β-Dihydroprogesterone
    • 5α-Dihydrocorticosterone
    • 5α-Dihydroprogesterone
    • 5β-Dihydroprogesterone
    • Allopregnanolone
    • Corticosterone
    • DHC
    • DHDOC
    • 11-Deoxycorticosterone
    • Epipregnanolone
    • Isopregnanolone
    • Pregnanolone
    • Pregnenolone
    • Pregnenolone sulfate
    • Progesterone
    • THB
    • THDOC
    • Androstanes: 3α-Androstanediol
    • 3α-Androstenol
    • 7-Keto-DHEA
    • 7α-Hydroxy-DHEA
    • 7β-Hydroxy-DHEA
    • 7α-Hydroxyepiandrosterone
    • 7β-Hydroxyepiandrosterone
    • Androsterone
    • DHEA
    • DHEA sulfate
    • Etiocholanolone
    • Pheromones: 3α-Androstenol
    • 3β-Androstenol
    • Androstadienol
    • Androstadienone
    • Androstenone
    • Androsterone
    • Estratetraenol


    • Vitamin D: 7-Dehydrocholesterol
    • Calcidiol/Calcifediol
    • Calcitriol
    • Cholecalciferol
    • Others: 7α-Hydroxycholesterol
    • 11α-Hydroxyprogesterone
    • 11β-Hydroxyprogesterone
    • Cholesterol sulfate


    • Antagonists: Aglepristone
    • Ketoconazole
    • Mifepristone
    • Ulipristal acetate

    Synthesis modifiers

    • Acetoxolone
    • Aminoglutethimide
    • Carbenoxolone
    • Enoxolone
    • Ketoconazole
    • Metyrapone
    • Mitotane
    • Trilostane
    • #WHO-EM
    • ‡Withdrawn from market
    • Clinical trials:
      • †Phase III
      • §Never to phase III

    See also
    Glucocorticoid receptor modulators
    Mineralocorticoids and antimineralocorticoids
    List of corticosteroids

    See also
    Receptor/signaling modulators
    Glucocorticoids and antiglucocorticoids
    Mineralocorticoid receptor modulators
    List of corticosteroids

    See also
    Receptor/signaling modulators
    Mineralocorticoids and antimineralocorticoids
    Glucocorticoid receptor modulators
    List of corticosteroids