Is Newer Always Better? – Here Are 11 Old-School Medications That Still Come Out on Top

Is Newer Always Better? – Here Are 11 Old-School Medications That Still Come Out on Top

<h1>Is Newer Always Better? – Here Are 11 Old-School Medications That Still Come Out on Top</h1>

Is Newer Always Better? – Here Are 11 Old-School Medications That Still Come Out on Top

Is Newer Always Better? – Here Are 11 Old-School Medications That Still Come Out on Top Dr. Sharon Orrange Dr. Orrange is an Associate Professor of Clinical Medicine in the Division of Geriatric, Hospitalist and General Internal Medicine at the Keck School of Medicine of USC. Posted on October 7, 2018 Newer classes of medications have transformed diabetes care and cancer treatment, but is newer always better? Patients often ask me if there is something “newer” than their current medication and if they should switch. My answer? Sometimes yes, sometimes no. Here are 11 medications that have been around forever (and I’m talking some from the 50’s) and are still recommended as first-line therapy. 1) Penicillin and amoxicillin for bacterial infections
Penicillin and amoxicillin are age-old antibiotics that are still first-line therapies for strep throat in adults today. Additionally, we use the intramuscular injection (IM) form of penicillin for first-line treatment of syphilis. Amoxicillin, used regularly since the 80’s, has broader coverage than penicillin (meaning that it fights more types of bacteria) and is used to treat ear infections, bronchitis and sinusitis. Still effective.
2) Nitrofurantoin for urinary tract infections
Nitrofurantoin (Macrodantin, Macrobid) is another oral antibiotic. It has been used over 40 years to treat urinary tract infections (UTIs), and can be used right after intercourse to prevent UTIs in women who get UTIs often.
How does it work? An enzyme in the bacteria breaks down nitrofurantoin to an active chemical that damages the bacterial cell. Macrobid , approved in the 90’s, now has a generic. It results in less stomach upset than Macrodantin .
3) Nitroglycerin for chest pain
Nitroglycerin tablets that you place under the tongue (sublingually) has an interesting backstory. This drug has been used for many many years—interestingly, without FDA approval—to treat chest pain caused by angina (or reduced blood flow to the heart). That is, until Nitrostat was approved in 2000.
Now, nitroglycerin 0.4 mg sublingual tablets come as generic nitroglycerin or brand-name drugs, Nitrostat and Nitrolingual . After so many years, nitroglycerin still works and is the first thing an ER doctor will give you if you show up with chest pain. Don’t miss out on savings! Get the best ways to save on your prescriptions delivered to your inbox. By signing up, I agree to GoodRx’s terms of service and privacy policy . 4) Hydrochlorothiazide and chlorthalidone for high blood pressure
Used for over 40 years, hydrochlorothiazide (HCTZ) and chlorthalidone are still recommended by American Heart Association and American College of Cardiology as first-line therapies to treat high blood pressure. Studies show that these thiazide diuretics are superior to newer medications in preventing heart attack and stroke—and they’re cheaper.
That’s why they should be the drugs of choice for initial treatment of hypertension in most patients who need drug therapy. Actually, chlorthalidone is turning out to be more effective than HCTZ and may become the new OG winner.
5) Amlodipine for high blood pressure
Amlodipine was approved as brand-name Norvasc in 1992—26 years ago—and is used to lower blood pressure. Calcium channel blockers like amlodipine are, in fact, considered the first-choice drug for blood pressure control specifically in African Americans.
6) Lisinopril for hypertension and heart failure
Lisinopril was approved as brand-name Zestril in 1987 and is another old-school medication recommended as first-line therapy for blood pressure and heart failure. Though dry cough is a well-known side effect occurring in about 5% of folks who take it, lisinopril is a cheap, effective medication.
7) Allopurinol for gout
Ever since the early 80’s, patients have been taking allopurinol once a day to prevent gout attacks. Despite our recent newcomer, Uloric (febuxostat), allopurinol is still recommended as first-line therapy for gout—because it’s safe, it works and it’s cheap. 8) Methotrexate for arthritis, psoriasis and some cancers
Methotrexate has been around since the 70’s and is still prescribed for rheumatoid arthritis, psoriasis and some cancers, including leukemias and lymphomas. Surprisingly, after almost 50 years since methotrexate was approved, we still don’t really know how it works to treat rheumatoid arthritis. Some say it’s by affecting immune function. In psoriasis, methotrexate is believed to target skin cells that quickly replicate. Yup, methotrexate is still used.
9) Trazodone for insomnia and depression
Trazodone is an antidepressant that was initially approved in the early 80’s (40 years ago!). It enhances serotonin levels in the brain by blocking the neurotransmitter from being reabsorbed. Trazodone is still widely prescribed for folks who have trouble sleeping and struggle with depression. Because it really works for insomnia, it has stayed popular.
10) Prednisone for inflammation-related diseases
Prednisone is an oral steroid approved in the 50’s. It’s still commonly prescribed for dozens of medical conditions, including asthma exacerbations, autoimmune hepatitis, multiple sclerosis and various skin conditions. A newer, sustained formulation of prednisone called Rayos was approved by the FDA in 2012, but it never really caught on because it’s so expensive. Prednisone is a powerful anti-inflammatory steroid that has never been replaced.
11) Plaquenil for autoimmune diseases
Plaquenil (hydroxychloroquine sulfate) has been around forever and yet, has never been knocked from its seat as a first-line therapy choice for autoimmune conditions like rheumatoid arthritis, lupus and Sjogren’s syndrome. It improves long-term functionality in patients with rheumatoid arthritis by blocking the activity of the immune system. Still great.
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What On Earth Is So Enticing About Scholastic Essay Publishing Firms?

What On Earth Is So Enticing About Scholastic Essay Publishing Firms?

What On Earth Is So Enticing About Scholastic Essay Publishing Firms? The Birth of Academic Essay Making People
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Migraine: Symptoms, Causes and Treatment | Health Info Ghana

<h1>Migraine: Symptoms, Causes and Treatment | Health Info Ghana</h1>

Migraine: Symptoms, Causes and Treatment | Health Info Ghana

Sensitivity to light and sound When to see a doctor
Migraines are often undiagnosed and untreated. If you regularly experience signs and symptoms of migraine attacks, keep a record of your attacks and how you treated them. Then make an appointment with your doctor to discuss your headaches.
Even if you have a history of headaches, see your doctor if the pattern changes or your headaches suddenly feel different.
See your doctor immediately or go to the emergency room if you have any of the following signs and symptoms, which may indicate a more serious medical problem: An abrupt, severe headache like a thunderclap Headache with fever, stiff neck, mental confusion, seizures, double vision, weakness, numbness or trouble speaking Headache after a head injury, especially if the headache gets worse A chronic headache that is worse after coughing, exertion, straining or a sudden movement New headache pain if you’re older than 50 Causes
Though migraine causes aren’t understood, genetics and environmental factors appear to play a role.
Migraines may be caused by changes in the brainstem and its interactions with the trigeminal nerve, a major pain pathway.
Imbalances in brain chemicals — including serotonin, which helps regulate pain in your nervous system — also may be involved. Researchers are still studying the role of serotonin in migraines.
Serotonin levels drop during migraine attacks. This may cause your trigeminal nerve to release substances called neuropeptides, which travel to your brain’s outer covering (meninges). The result is migraine pain. Other neurotransmitters play a role in the pain of migraine, including calcitonin gene-related peptide (CGRP). Migraine triggers
A number of factors may trigger migraines, including: Hormonal changes in women. Fluctuations in estrogen seem to trigger headaches in many women. Women with a history of migraines often report headaches immediately before or during their periods, when they have a major drop in estrogen.Others have an increased tendency to develop migraines during pregnancy or menopause.Hormonal medications, such as oral contraceptives and hormone replacement therapy, also may worsen migraines. Some women, however, find their migraines occur less often when taking these medications. Foods. Aged cheeses, salty foods and processed foods may trigger migraines. Skipping meals or fasting also can trigger attacks. Food additives. The sweetener aspartame and the preservative monosodium glutamate (MSG), found in many foods, may trigger migraines. Drinks. Alcohol, especially wine, and highly caffeinated beverages may trigger migraines. Stress. Stress at work or home can cause migraines. Sensory stimuli. Bright lights and sun glare can induce migraines, as can loud sounds. Strong smells — including perfume, paint thinner, secondhand smoke and others — can trigger migraines in some people. Changes in wake-sleep pattern. Missing sleep or getting too much sleep may trigger migraines in some people, as can jet lag. Physical factors. Intense physical exertion, including sexual activity, may provoke migraines. Changes in the environment. A change of weather or barometric pressure can prompt a migraine. Medications. Oral contraceptives and vasodilators, such as nitroglycerin, can aggravate migraines. Risk factors
Several factors make you more prone to having migraines, including: Family history. If you have a family member with migraines, then you have a good chance of developing them too. Age. Migraines can begin at any age, though the first often occurs during adolescence. Migraines tend to peak during your 30s, and gradually become less severe and less frequent in the following decades. Sex. Women are three times more likely to have migraines. Headaches tend to affect boys more than girls during childhood, but by the time of puberty and beyond, more girls are affected. Hormonal changes. If you are a woman who has migraines, you may find that your headaches begin just before or shortly after onset of menstruation.They may also change during pregnancy or menopause. Migraines generally improve after menopause.Some women report that migraine attacks begin during pregnancy, or their attacks worsen. For many, the attacks improved or didn’t occur during later stages in the pregnancy. Migraines often return during the postpartum period. Complications
Sometimes your efforts to control your migraine pain cause problems, such as: Abdominal problems. Certain pain relievers called nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin IB, others), may cause abdominal pain, bleeding, ulcers and other complications, especially if taken in large doses or for a long period of time. Medication-overuse headaches. Taking over-the-counter or prescription headache medications more than 10 days a month for three months or in high doses may trigger serious medication-overuse headaches.Medication-overuse headaches occur when medications stop relieving pain and begin to cause headaches. You then use more pain medication, which continues the cycle. Serotonin syndrome. Serotonin syndrome is a rare, potentially life-threatening condition that occurs when your body has too much of the nervous system chemical called serotonin.While the risk is considered extremely low, taking migraine medications called triptans and antidepressants known as selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs) may increase the risk of serotonin syndrome. These medications naturally raise serotonin levels, and it is possible that combining them could cause levels that are too high.Triptans and SSRIs or SNRIs may be used together, but it’s important to watch out for possible symptoms of serotonin syndrome such as changes in cognition, behavior and muscle control (such as involuntary jerking).Triptans include medications such as sumatriptan (Imitrex) or zolmitriptan (Zomig). Some common SSRIs include sertraline (Zoloft), fluoxetine (Sarafem, Prozac) and paroxetine (Paxil). SNRIs include duloxetine (Cymbalta) and venlafaxine (Effexor XR).
Also, some people experience complications from migraines such as: Chronic migraine. If your migraine lasts for 15 or more days a month for more than three months, you have chronic migraine. Status migrainosus. People with this complication have severe migraine attacks that last for longer than three days. Persistent aura without infarction. Usually an aura goes away after the migraine attack, but sometimes aura lasts for more than one week afterward. A persistent aura may have similar symptoms to bleeding in the brain (stroke), but without signs of bleeding in the brain, tissue damage or other problems. Migrainous infarction. Aura symptoms that last longer than one hour can signal a loss of blood supply to an area of the brain (stroke), and should be evaluated. Doctors can conduct neuroimaging tests to identify bleeding in the brain.
Diagnosis
If you have migraines or a family history of migraines, a doctor trained in treating headaches (neurologist) will likely diagnose migraines based on your medical history, symptoms, and a physical and neurological examination.
Your doctor may also recommend more tests to rule out other possible causes for your pain if your condition is unusual, complex or suddenly becomes severe. Blood tests. Your doctor may order these to test for blood vessel problems, infections in your spinal cord or brain, and toxins in your system. Magnetic resonance imaging (MRI). An MRI uses a powerful magnetic field and radio waves to produce detailed images of the brain and blood vessels.MRI scans help doctors diagnose tumors, strokes, bleeding in the brain, infections, and other brain and nervous system (neurological) conditions. Computerized tomography (CT) scan. A CT scan uses a series of X-rays to create detailed cross-sectional images of the brain. This helps doctors diagnose tumors, infections, brain damage, bleeding in the brain and other possible medical problems that may be causing headaches. Spinal tap (lumbar puncture). Your doctor may recommend a spinal tap (lumbar puncture) if he or she suspects infections, bleeding in the brain or another underlying condition.In this procedure, a thin needle is inserted between two vertebrae in the lower back to remove a sample of cerebrospinal fluid for analysis in a lab.
Treatment
Migraine treatments can help stop symptoms and prevent future attacks.
Many medications have been designed to treat migraines. Some drugs often used to treat other conditions also may help relieve or prevent migraines. Medications used to combat migraines fall into two broad categories: Pain-relieving medications. Also known as acute or abortive treatment, these types of drugs are taken during migraine attacks and are designed to stop symptoms. Preventive medications. These types of drugs are taken regularly, often on a daily basis, to reduce the severity or frequency of migraines.
Your treatment strategy depends on the frequency and severity of your headaches, the degree of disability your headaches cause, and your other medical conditions.
Some medications aren’t recommended if you’re pregnant or breast-feeding. Some medications aren’t given to children. Your doctor can help find the right medication for you. Pain-relieving medications
Take pain-relieving drugs as soon as you experience signs or symptoms of a migraine for the best results. It may help if you rest or sleep in a dark room after taking them. Medications include: Pain relievers. Aspirin or ibuprofen (Advil, Motrin IB, others) may help relieve mild migraines.Acetaminophen (Tylenol, others), also may help relieve mild migraines in some people.Drugs marketed specifically for migraines, such as the combination of acetaminophen, aspirin and caffeine (Excedrin Migraine), also may ease moderate migraine pain. They aren’t effective alone for severe migraines.If taken too often or for long periods of time, these medications can lead to ulcers, gastrointestinal bleeding and medication-overuse headaches.
The prescription pain reliever indomethacin may help thwart a migraine and is available in suppository form, which may be helpful if you’re nauseated. Triptans. These medications are often used in treating migraines. Triptans make blood vessels constrict and block pain pathways in the brain.Triptans effectively relieve the pain and other symptoms that are associated with migraines. They are available in pill, nasal spray and injection form.Triptan medications include sumatriptan (Imitrex), rizatriptan (Maxalt), almotriptan (Axert), naratriptan (Amerge), zolmitriptan (Zomig), frovatriptan (Frova) and eletriptan (Relpax).Side effects of triptans include reactions at the injection site, nausea, dizziness, drowsiness and muscle weakness. They aren’t recommended for people at risk of strokes and heart attacks.
A single-tablet combination of sumatriptan and naproxen sodium (Treximet) has proved to be more effective in relieving migraine symptoms than either medication on its own. Ergots. Ergotamine and caffeine combination drugs (Migergot, Cafergot) are less effective than triptans. Ergots seem most effective in those whose pain lasts for more than 48 hours. Ergots are most effective when taken soon after migraine symptoms start.Ergotamine may worsen nausea and vomiting related to your migraines, and it may also lead to medication-overuse headaches.Dihydroergotamine (D.H.E. 45, Migranal) is an ergot derivative that is more effective and has fewer side effects than ergotamine. It’s also less likely to lead to medication-overuse headaches. It’s available as a nasal spray and in injection form. Anti-nausea medications. Medication for nausea is usually combined with other medications. Frequently prescribed medications are chlorpromazine, metoclopramide (Reglan) or prochlorperazine (Compro). Opioid medications. Opioid medications containing narcotics, particularly codeine, are sometimes used to treat migraine pain for people who can’t take triptans or ergots. Narcotics are habit-forming and are usually used only if no other treatments provide relief. Glucocorticoids (prednisone, dexamethasone). A glucocorticoid may be used with other medications to improve pain relief. Glucocorticoids shouldn’t be used frequently to avoid side effects. Preventive medications
You may be a candidate for preventive therapy if: You have four or more debilitating attacks a month If attacks last more than 12 hours If pain-relieving medications aren’t helping If your migraine signs and symptoms include a prolonged aura or numbness and weakness
Preventive medications can reduce the frequency, severity and length of migraines and may increase the effectiveness of symptom-relieving medicines used during migraine attacks. It may take several weeks to see improvements in your symptoms.
Your doctor may recommend daily preventive medications, or only when a predictable trigger, such as menstruation, is approaching.
Preventive medications don’t always stop headaches completely, and some drugs cause serious side effects. If you have had good results from preventive medicine and your migraines are well-controlled, your doctor may recommend tapering off the medication to see if your migraines return without it.
The most common medications for migraine prevention include: Cardiovascular drugs. Beta blockers, which are commonly used to treat high blood pressure and coronary artery disease, may reduce the frequency and severity of migraines.The beta blockers propranolol (Inderal LA, Innopran XL, others), metoprolol tartrate (Lopressor) and timolol (Betimol) have proved effective for preventing migraines. Other beta blockers are also sometimes used for treatment of migraine. You may not notice improvement in symptoms for several weeks after taking these medications.If you’re older than age 60, use tobacco, or have certain heart or blood vessel conditions, doctors may recommend you take a different medication.Another class of cardiovascular medications (calcium channel blockers) used to treat high blood pressure also may be helpful in preventing migraines and relieving symptoms. Verapamil (Calan, Verelan, others) is a calcium channel blocker that may help prevent migraines with aura.
In addition, the angiotensin-converting enzyme inhibitor lisinopril (Zestril) may be useful in reducing the length and severity of migraines. Antidepressants. Tricyclic antidepressants may be effective in preventing migraines, even in people without depression.Tricyclic antidepressants may reduce the frequency of migraines by affecting the level of serotonin and other brain chemicals. Amitriptyline is the only tricyclic antidepressant proved to effectively prevent migraines. Other tricyclic antidepressants are sometimes used because they may have fewer side effects than amitriptyline.These medications can cause sleepiness, dry mouth, constipation, weight gain and other side effects.Another class of antidepressants called selective serotonin reuptake inhibitors hasn’t been proved to be effective for migraine prevention. These drugs may even worsen or trigger headaches.
However, research suggests that one serotonin and norepinephrine reuptake inhibitor, venlafaxine (Effexor XR), may be helpful in preventing migraines. Anti-seizure drugs. Some anti-seizure drugs, such as valproate (Depacon) and topiramate (Topamax), seem to reduce the frequency of migraines.In high doses, however, these anti-seizure drugs may cause side effects. Valproate sodium may cause nausea, tremor, weight gain, hair loss and dizziness. Valproate products should not be used in pregnant women or women who may become pregnant.Topiramate may cause diarrhea, nausea, weight loss, memory difficulties and concentration problems. OnabotulinumtoxinA (Botox). OnabotulinumtoxinA (Botox) has been shown to be helpful in treating chronic migraines in adults.During this procedure, onabotulinumtoxinA is injected into the muscles of the forehead and neck. When this is effective, the treatment usually needs to be repeated every 12 weeks. Pain relievers. Taking nonsteroidal anti-inflammatory drugs, especially naproxen (Naprosyn), may help prevent migraines and reduce symptoms. Alternative medicine
Nontraditional therapies may be helpful if you have chronic migraine pain. Acupuncture. Clinical trials have found that acupuncture may be helpful for headache pain. In this treatment, a practitioner inserts many thin, disposable needles into several areas of your skin at defined points. Biofeedback. Biofeedback appears to be effective in relieving migraine pain. This relaxation technique uses special equipment to teach you how to monitor and control certain physical responses related to stress, such as muscle tension. Massage therapy. Massage therapy may help reduce the frequency of migraines. Researchers continue to study the effectiveness of massage therapy in preventing migraines. Cognitive behavioral therapy. Cognitive behavioral therapy may benefit some people with migraines. This type of psychotherapy teaches you how behaviors and thoughts affect how you perceive pain. Herbs, vitamins and minerals. There is some evidence that the herbs feverfew and butterbur may prevent migraines or reduce their severity, though study results are mixed. Butterbur isn’t recommended because of long-term safety concerns.A high dose of riboflavin (vitamin B-2) also may prevent migraines or reduce the frequency of headaches.Coenzyme Q10 supplements may decrease the frequency of migraines, but larger studies are needed.Due to low magnesium levels in some people with migraines, magnesium supplements have been used to treat migraines, but with mixed results.
Ask your doctor if these treatments are right for you. Don’t use feverfew, riboflavin or butterbur if you’re pregnant or without first talking with your doctor.
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Stanford researchers are launching a company to treat inflammatory diseases with marijuana, CBD – Business Insider

<h1>Stanford researchers are launching a company to treat inflammatory diseases with marijuana, CBD – Business Insider</h1>

Stanford researchers are launching a company to treat inflammatory diseases with marijuana, CBD – Business Insider

Two high-profile Stanford researchers are launching a medical company to develop marijuana-based therapies for conditions like arthritis, Crohn’s disease, and multiple sclerosis. Called Katexco Pharmaceuticals, the company will be based in Canada but maintain a US subsidiary in Silicon Valley, California’s tech and startup hub. The company is specifically exploring CBD , the compound in marijuana that is not linked with a high. There’s some evidence that CBD might help with conditions like Crohn’s disease, but the scientists will need to do big clinical trials to know for sure. How good is marijuana at treating inflammation, a condition marked by swelling and redness that’s also a cause of an entire class of diseases?
Two high-profile Stanford researchers are about to find out. They are specifically exploring CBD , the compound in cannabis that has some medicinal properties and doesn’t get you high.
On Wednesday, Jonathan Rothbard and Lawrence Steinman — both of whom have decades of experience at Stanford University Medical School and have previously founded drug companies — launched a new medical company aimed at developing CBD-based therapies for conditions like arthritis, inflammatory bowel disease, and multiple sclerosis. The common hallmark of all of those conditions is that they are inflammatory diseases, or diseases in which the body’s normal protective response to external threats like infections spirals out of control.
Called Katexco Pharmaceuticals, Rothbard and Steinman’s new private equity-backed company will be based in Toronto, Canada but maintain a US subsidiary in Silicon Valley, California’s lucrative startup hub.
The new company is part of a bigger trend. A handful of pharmaceutical startups — some supported by larger drug companies like Johnson & Johnson — have their headquarters north of the border , where the legal framework for marijuana is clearer. In the US, despite a recent green light for CBD from two federal agencies , the legality of marijuana as a whole plant remains murky.
Katexco’s goal is to develop the first CBD-based drugs to treat inflammatory conditions.
While other drugs like Remicade and prednisone already treat these conditions, the researchers hope the new drug will produce fewer negative side effects. They should know: joining Rothbard and Steinman in their efforts is Sir Marc Feldmann, the Oxford professor who helped develop Remicade.
Rothbard and Steinman told Business Insider that they have exclusive technology licenses from Stanford to pursue the treatments, which also involve creating a non-addictive form of nicotine to complement the effects of the CBD. Both drugs would act on a receptor found in the brain and throughout the body called the A7 receptor.
“We’re making compounds that hit that receptor and turn on the anti-inflammatory response,” Steinman told Business Insider.
Why CBD could hold promise for inflammatory diseases like MS and inflammatory bowel disease
AP Photo/Ted S. Warren The scientific research on CBD, the second main compound in marijuana after THC, remains largely in its infancy . Researchers have linked the ingredient with a range of potential therapeutic benefits, from reducing pain to suppressing anxiety. The most well-researched of those benefits is related to how the drug works in people with two rare forms of epilepsy . In children with those forms of the disease, an ultra-high dose of CBD appears to powerfully curb seizures. These findings enabled the landmark approval this summer of America’s first CBD-based drug , a syrup called Epidiolex .
But for CBD to have therapeutic benefits on diseases like MS and Crohn’s (a form of inflammatory bowel disease characterized by abdominal cramping, weight loss, and diarrhea), it would likely need to reduce inflammation. That’s something that marijuana as a whole appears to do .
In 2005 for example, the scientists behind a small, preliminary study of people with rheumatoid arthritis (one of the conditions Katexco said it aims to study), concluded that a THC- and CBD-containing drug called Sativex appeared to significantly reduce pain. And the authors of a small 2014 study of people with Crohn’s disease found that 10 out of 11 subjects given cannabis saw a decrease in symptoms, compared with just four out of 10 subjects given a placebo.
The problem is that most of the existing research looks at the effects of the whole plant — THC, CBD, and all the rest. In order to identify how CBD affects these conditions, researchers need to study it in isolation like they did for Epidiolex. Which is precisely what Rothbard and Steinman aim to do.
‘A whole new frontier ahead of us’
From left to right: Lawrence Steinman, Jonathan Rothbard, and Sir Marc Feldmann. Katexco Pharmaceuticals Rothbard, Steinman, and Feldmann are all heavy-hitters in the pharma world. As a result, they’re confident that their approach will lead to new treatments within the next two years, Rothbard and Steinman told Business Insider. “We have a whole new frontier ahead of us that could lead to pharmaceuticals for a variety of clinical needs that aren’t currently being met,” Steinman said.
He’s chairman of Katexco, while Rothbard is the company’s chief executive officer and chief scientific officer. Feldmann, the researcher who helped develop Remicade, is Katexco’s third co-founder and chair of its scientific advisory board.
Rothbard currently works as a senior researcher at Stanford. In the 1990s, he founded Amylin Pharmaceuticals, a drug company that was acquired by drug giant Bristol-Myers Squibb in 2012. Steinman is an immunologist at Stanford who leads a lab dedicated to the study of autoimmune diseases. He already has four other life science companies under his belt and currently leads the scientific advisory board for one of them, a private drug development company called Transparency Life Sciences.
The A7 receptor During the course of Rothbard’s research at Stanford, he did lots of work on a special receptor known as the A7 receptor. Initially identified by scientists only in the brain, the receptor was once a primary target for a handful of pharmaceutical companies hoping to find new treatments for Alzheimer’s and schizophrenia. Their efforts ultimately failed.
But Rothbard found the receptor outside the brain as well. Most importantly, he found it all along the gut, which is where inflammatory bowel disease appears to arise. Currently, the symptoms of the disease can only be managed; there is no cure.
He and Steinman believe that by narrowly targeting the A7 receptor in the gut with both CBD and nicotine (which they claim have synergistic effects), they’ll reduce inflammation and avoid the issues of addiction which arise when nicotine enters the brain.
The team is planning to run clinical trials to test formulations of the drug as soon as next year. The first condition they plan to pursue is constipation, which has been on the rise thanks to high opioid prescribing rates. (Constipation is a side effect of opioids, and is also linked to inflammation.) They expect the results of those trials in 2020. Depending on the outcomes, the team will decide what condition to pursue next.
“You’re not necessarily going to change the world the first time you try,” Rothbard said.
This is a subscriber-only story. To read the full article, simply click here to claim your deal and get access to all exclusive Business Insider PRIME content.

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What to know about steroids for COPD

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