Today was my 10th, and last, Entivyo infusion- because they just aren’t working. Onto Stelara – but first!! A 60mg prednisone taper! 😞

<h1>Today was my 10th, and last, Entivyo infusion- because they just aren’t working. Onto Stelara – but first!! A 60mg prednisone taper! 😞</h1>

Today was my 10th, and last, Entivyo infusion- because they just aren’t working. Onto Stelara – but first!! A 60mg prednisone taper! 😞

Today was my 10th, and last, Entivyo infusion- because they just aren’t working. Onto Stelara – but first!! A 60mg prednisone taper! 😞” https://i.redd.it/u0tn2eu1hck21.jpg

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Originally Posted by THOR 70 Obviously you know what you’re doing, but at which point do you taper the external inputs and work to obtain homeostasis? Or is that what you’re using these tools to minimize pains on the path to homeostasis? Treating the akasthesia was the right choice. If I had let it run it very well probably would have induced a psychotic state. Akasthesia in someone already experiencing a mental health crisis is a psychiatric emergency.
And I get what you’re saying, but not substituting drugs for more drugs. I’m completely off opioids at this point (thank you tianeptine) and on a minimal dose of prednisone, which will be completely withdrawn by weeks’ end.
The promethazine was to try and sleep without dream torture, but in retrospect suppressing my dreams is suppressing emotion that needs to be addressed and as unpleasant as the dreams are, they need to happen. Lesson learned.
The T4 is somewhat of a necessity at this point — my basal temp has been around 96°. Without adequate thyroid hormone levels and with a current EBV infection, my immune system will be taking a massive hit.
I’m trying to make the transition to water fasting as gentle as possible, and if this involves judicious use of other drugs to ease that transition then that’s what I’ll do. The end result is all that matters to me.

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Are you taking prednisone for your colitis/Crohn’s? If so, that could be some of it. I was put on prednisone (high dose) and could never really taper off of it. I gained a lot of weight (some of it water). But it just made me hungry all the time. My point is that that medicine makes you hungry all the time. I couldn’t p ractice self control but maybe you can. otherwise, try to eat filling foods with fiber if your body tolerates it. That may help.

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Hey hon. I’ve done four IVFs and the only one that resulted in a take home baby , I was on Prednisone. I had the best blast rate and everything that time. I was on Prednisone 20 mg daily starting a few weeks before stims all the way thru 12 weeks pg, then tapered off between 12&20 weeks .

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Duration & Treatment of Musculoskeletal Symptoms of Immunotherapy-Induced Arthritis

<h1>Duration & Treatment of Musculoskeletal Symptoms of Immunotherapy-Induced Arthritis</h1>

Duration & Treatment of Musculoskeletal Symptoms of Immunotherapy-Induced Arthritis

The Latest Data on Cancer Immunotherapy’s Interaction with Autoimmunity
To better characterize and understand musculoskeletal irAEs, Melanie H. Smith, MD, PhD, and Anne R. Bass, MD, conducted a retrospective chart review. They identified 10 patients with musculoskeletal irAEs, who received long-term follow up, and were first seen by one of them between 2014 and 2016. All patients had been treated for cancer with immune checkpoint inhibitors at Memorial Sloan Kettering Cancer Center. The research was an attempt to illustrate the required duration of immunosuppressive treatment in these patients. The results were published in the March 2019 issue of Arthritis Care & Research .
The Results “Patients experiencing musculoskeletal irAEs can have a wide variety of manifestations from oligoarthritis and tenosynovitis, to [polymyalgia rheumatica], to a polyarthritis consistent with [rheumatoid arthritis],” write the authors. “These irAEs had a delayed onset after initiation of immunotherapy, and the majority of patients required prednisone 10–20 mg daily for at least six months to control their symptoms.”
The mean age of the patients was 63.2 years old and 50% were female. For their cancer, seven patients were treated with a combination of checkpoint inhibitors and three with monotherapy. The average time from the first dose of immunotherapy until joint involvement was 6.3 months. Four patients developed inflammatory polyarthritis, four developed oligoarthritis and two developed tenosynovitis. Six patients were anti-nuclear antibody positive, and two had anti-cyclic citrullinated peptide antibodies.
The two patients with the shortest time to the onset of musculoskeletal symptoms either had symptoms prior to initiating immunotherapy or had a strong genetic predisposition. The authors note, “For rheumatologic irAEs, the removal of immune inhibition may unmask native disease, and the delayed onset of symptoms may reflect a preclinical phase similar to that seen in non–immunotherapy-related rheumatic disease.”
Treatment: All 10 patients were treated with systemic corticosteroids, with patients generally advocating for the lowest dose of steroid possible. Six patients achieved good symptom control with 20 mg of prednisone or less daily. Three patients were started on disease-modifying anti-rheumatic drugs, and one patient required a tumor necrosis factor inhibitor (infliximab) to allow steroid tapering.
“In contrast to an earlier case series that suggested that high-dose steroids are required for arthritis control, we found that lower doses of prednisone were usually adequate,” write the authors. Additionally the authors write, “Based on our case series, the duration of musculoskeletal irAEs appears to be much longer [than other irAEs]: The mean symptom duration after stopping immunotherapy was nine months.”

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Daisy other updates

<h1>Daisy other updates</h1>

Daisy other updates

Hi all. Thank you so much for all the support while Daisy was sick. It means more than we could ever express.
As an update, after bringing Daisy home from ICU she regained her strength and started eating and gaining weight. Her best weeks to date was probably the second and third week after she returned home from ICU. From there the improvement tapered off. She was on prednisone for about a month but due to very high liver enzyme values and the return of some of the Cushing symptoms we slowly pulled her off the prednisone per the vets instructions. We’ve been going to the vet every 2 to 3 weeks for blood work. The liver enzymes have dropped a little but are still very high. Overall she’s doing ok. She has good days and she has bad days. Some days we are very optimistic and others where we are worried to death. We are just taking it one day at a time.
As to other life updates. I posted in December about the possibility of a puppy. That was before D got sick. After giving it a lot of thought, DH decided that he wanted to move forward with our original plans. While it seems a little crazy, I get where he is coming from and we’re excited and nervous for our new addition (a black male) that we are picking up at the beginning of April.

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Spurfy’s Fasting Log

<h1>Spurfy’s Fasting Log</h1>

Spurfy’s Fasting Log

After careful consideration I’ve decided that I’m going to need to taper off of narcotic pain meds and prednisone/oral hydrocortisone before I start full-on fasting. I’m at the point where serious adrenal suppression has probably occurred and stopping the corticosteroids cold-turkey just isn’t an option without considerable risk.
As many of you probably know, cortisol elevates during fasting but not if negative feedback inhibition from exogenous corticosteroids has shut down the adrenal glands. This is no different than the HPG-axis suppression from exogenous androgens, except that one actually needs cortisol to live, while testosterone isn’t needed to sustain life.
Also, glucocorticoids elevate both glucose and insulin, and ketosis will suffer greatly if I attempt to fast while I’m tapering.
The opioids I will also be tapering off of and if withdrawal is or becomes an issue I have gabapentin, baclofen, and diazepam to lessen the discomfort and to make the transition smoother.
Starting today until March 20, I’ll be consuming a single small ketogenic meal after sunset with no water during the day. For the first few days I’ll probably be taking 120-180 mg of pseudoephedrine upon waking to help control my appetite, as both opioids and corticosteroids make me constantly hungry.
Starting March 21, at the conclusion of my drug tapers, I will begin fasting with only water, lime juice, electrolytes, black coffee or green tea (if needed), oral hydrocortisone in the morning prior to any anticipated heavy exertion (if any), tianeptine (if needed for mood), a nicotine patch if my energy really starts crashing or the pain from my discs or osteoarthritis becomes too overwhelming, and melatonin at bedtime.
For exercise I will be walking daily once the actual fasting starts. There will likely be no before and after pics, and no daily weigh-in. I’m doing this as a gift to my son, who is 4, who needs me to live a very long and healthy life. All previous fasts have had a large aesthetic element but I want this one to be completely selfless. I’ll log my weight once per week.
I will not read or watch any news, nor any TV or movies except uplifting documentaries, and the only social media I will be active in is Instagram (pics of my son) and this forum.
At the conclusion (which right now is open-ended) I hope to have healed my body enough that I can begin training again, and most-importantly to try to see life as a gift instead of an affliction. Presently, the only time I’m not abjectly miserable is the short period each week I get with my son. It would be nice to be able to see at least some of the joy and wonder and amazement of this world like my son does, instead of seething with sadness, anger, resentment, and regret. I can only barely remember what it felt like to see my life as anything but a tremendous burden. Except for when I’m with my son? all of my hope, optimism, inspiration, humor, joy, gratitude, compassion, empathy, and warmth are just gone and no matter how deeply I dig, I just can’t find them. I’m constantly filled with emptiness so profound that I have stopped loving everyone but my son and have basically abandoned all of my friendships. I used to want to change the world for the better — now I find myself hoping for a nuclear war or Yellowstone eruption. I don’t want this any more.
S

Read More…

Spurfy’s Fasting Log

<h1>Spurfy’s Fasting Log</h1>

Spurfy’s Fasting Log

After careful consideration I’ve decided that I’m going to need to taper off of narcotic pain meds and prednisone/oral hydrocortisone before I start full-on fasting. I’m at the point where serious adrenal suppression has probably occurred and stopping the corticosteroids cold-turkey just isn’t an option without considerable risk.
As many of you probably know, cortisol elevates during fasting but not if negative feedback inhibition from exogenous corticosteroids has shut down the adrenal glands. This is no different than the HPG-axis suppression from exogenous androgens, except that one actually needs cortisol to live, while testosterone isn’t needed to sustain life.
Also, glucocorticoids elevate both glucose and insulin, and ketosis will suffer greatly if I attempt to fast while I’m tapering.
The opioids I will also be tapering off of and if withdrawal is or becomes an issue I have gabapentin, baclofen, and diazepam to lessen the discomfort and to make the transition smoother.
Starting today until March 20, I’ll be consuming a single small ketogenic meal after sunset with no water during the day. For the first few days I’ll probably be taking 120-180 mg of pseudoephedrine upon waking to help control my appetite, as both opioids and corticosteroids make me constantly hungry.
Starting March 21, at the conclusion of my drug tapers, I will begin fasting with only water, lime juice, electrolytes, black coffee or green tea (if needed), oral hydrocortisone in the morning prior to any anticipated heavy exertion (if any), tianeptine (if needed for mood), a nicotine patch if my energy really starts crashing or the pain from my discs or osteoarthritis becomes too overwhelming, and melatonin at bedtime.
For exercise I will be walking daily once the actual fasting starts. There will be likely be no before and after pics, and no daily weigh-in. I’m doing this as a gift to my son, who is 4, who needs me to live a very long and healthy life. All previous fasts have had a large aesthetic element but I want this one to be completely selfless. I’ll log my weight once per week.
I will not read or watch any news, nor any TV or movies except uplifting documentaries, and the only social media I will be active in is Instagram (pics of my son) and this forum.
At the conclusion (which right now is open-ended) I hope to have healed my body enough that I can begin training again, and most-importantly to try to see life as a gift instead of an affliction. Presently, the only time I’m not abjectly miserable is the short period each week I get with my son. It would be nice to be able to see at least some of the joy and wonder and amazement of this world like my son does, instead of seething with sadness, anger, resentment, and regret. I can only barely remember what it felt like to see my life as anything but a tremendous burden. Except for when I’m with my son? all of my hope, optimism, inspiration, humor, joy, gratitude, compassion, empathy, and warmth are just gone and no matter how deeply I dig, I just can’t find them. I’m constantly filled with emptiness so profound that I have stopped loving everyone but my son and have basically abandoned all of my friendships. I used to want to change the world for the better — now I find myself hoping for a nuclear war or Yellowstone eruption. I don’t want this any more.
S

Read More…

<h1></h1>

he novice cannot attendBegin by describing the method you chose and why this method was the most appropriate. In doing so, youat the moment of comp(Wiley)frustration.B. Discussion of results of ateaching of teachers about researchterm memorynovice/expert differences you could talk with a scientist about howtime.administration of instrument orprovide guidance as needed at this point but expect you to work as independently as possible.for example, foreshadowing, referral, comparisons with relateda student out of a prior misconception orexactly.reflectionthis mappingen better,,This chapter addresses the results from your data an,
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Spurfy’s Fasting Log

<h1>Spurfy’s Fasting Log</h1>

Spurfy’s Fasting Log

After careful consideration I’ve decided that I’m going to need to taper off of narcotic pain meds and prednisone/oral hydrocortisone before I start full-on fasting. I’m at the point where serious adrenal suppression has probably occurred and stopping the corticosteroids cold-turkey just isn’t an option without considerable risk.
As many of you probably know, cortisol elevates during fasting but not if negative feedback inhibition from exogenous corticosteroids has shut down the adrenal glands. This is no different than the HPG-axis suppression from exogenous androgens, except that one actually needs cortisol to live, while testosterone isn’t needed to sustain life.
Also, glucocorticoids elevate both glucose and insulin, and ketosis will suffer greatly if I attempt to fast while I’m tapering.
The opioids I will also be tapering off of and if withdrawal is or becomes an issue I have gabapentin, baclofen, and diazepam to lessen the discomfort and to make the transition smoother.
Starting today until March 20, I’ll be consuming a single small ketogenic meal after sunset with no water during the day. For the first few days I’ll probably be taking 120-180 mg of pseudoephedrine upon waking to help control my appetite, as both opioids and corticosteroids make me constantly hungry.
Starting March 21, at the conclusion of my drug tapers, I will begin fasting with only water, lime juice, electrolytes, black coffee or green tea (if needed), oral hydrocortisone in the morning prior to any anticipated heavy exertion (if any), tianeptine (if needed for mood), a nicotine patch if my energy really starts crashing or the pain from my crusted discs becomes too overwhelming, and melatonin at bedtime.
For exercise I will be walking daily once the actual fasting starts. There will be likely be no before and after pics, and no daily weigh-in. I’m doing this as a gift to my son, who is 4, who needs me to live a very long and healthy life. All previous fasts have had a large aesthetic element but I want this one to be completely selfless. I’ll log my weight once per week.
I will not read or watch any news, nor any TV or movies except uplifting documentaries, and the only social media I will be active in is Instagram (pics of my son) and this forum.
At the conclusion I hope to have healed my body enough that I can begin training again, and most-importantly to try to see life as a gift instead of an affliction. Presently, the only time I’m not abjectly miserable is the short period each week I get with my son. It would be nice to be able to see at least some of the joy and wonder and amazement of this world like my son does, instead of seething with sadness, anger, resentment, and regret. I can only barely remember what it felt like to see my life as anything but a tremendous burden. Except for when I’m with my son? all of my hope, optimism, inspiration, humor, joy, gratitude, compassion, empathy, and warmth are just gone and no matter how deeply I dig, I just can’t find them. I’m constantly filled with emptiness so profound that I have stopped loving everyone but my son and have basically abandoned all of my friendships. I used to want to change the world for the better — now I find myself hoping for a nuclear war or Yellowstone eruption. I don’t want this any more.
S

Read More…